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Current Drug Delivery

Author(s): Fadia Ijbara, Dua’a M. Marzouqa, Murad A. AlDamin and Hamdallah A. Hodali*

DOI: 10.2174/1567201816666191106102740

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Release Kinetics of Nicotine Loaded onto Mesoporous Silicate Materials for Use in Nicotine Replacement Therapy

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Abstract

Objective: In this work, the loading of nicotine onto mesoporous silicate materials and its release into a phosphate buffer solution at 37°C were investigated.

Methods: The mesoporous silicate materials designated as MCM-41 were prepared with different pore sizes via using alkyltrimethylammonium bromide surfactants with different alkyl chain lengths of carbon atoms 12, 14, and 16. The mesoporous silicate systems were characterized by X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), N2-adsorption–desorption isotherms, and FT-IR spectroscopy.

Results: Loading of nicotine was confirmed by FTIR and thermal gravimetric analysis and was determined by High-Performance Liquid Chromatography (HPLC).

Conclusion: A slight increase in loading capacity with increasing pore size was observed, with a loading capacity of about 17% for MCM-41(16). The release of nicotine was monitored by HPLC and was almost complete for MCM-41(14) and MCM-41(16) in 8 h.

Keywords: Nicotine, MCM-41, mesoporous materials, drug delivery, HPLC, FTIR, NRT.

Graphical Abstract

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