Abstract
Background: Tablets being the conventional dosage forms can be modified for providing
the desired therapeutic effect to the patients. The network of matrix in the tablet allows the drug release
to be slowed down considerably.
Objective: The prime objective of the study was to formulate sustained release glibenclamide matrix
tablets using locust bean gum and karaya gum as a matrix polymer.
Methods: Tablets were formulated by optimization using 32 factorial designs by direct compression
method using different drug: polymer concentrations. The dependent variables selected were % cumulative
drug release (Y1) and % drug content (Y2). The independent variables are the amount of locust
bean gum (X1) and karayagum (X2). Drug-polymer compatibility studies were confirmed by
FTIR and DSC. The pre-compression properties of powder were assessed indicating a good flow
property. The evaluation results of the tablets were found to be within the Indian Pharmacopoeial
limit. In this work, the effect of diluents type and polymer type was studied on the drug release with
its increase in concentration.
Results: All the formulations showed retarded drug release as the concentration of the polymer was
increased. Formulation F8 was selected as the best-optimized formulation with about 100.56% drug
release within 12 h. Release kinetics was carried out and it was found to be zero-order release and
from assay, drug content was found to be in limits.
Conclusion: ANOVA analysis indicated that the studied variables affected the response variables
significantly. The optimized formulation was stable. Hence, it is concluded that the Glibenclamide
sustained release matrix tablet containing natural polymers were successfully formulated by using 32
factorial design.
Keywords:
ANOVA analysis, DSC, karaya gum, locust bean gum, matrix tablet, P-XRD.
Graphical Abstract
[3]
Patel MP, Patel MM, Patel KN, Patel DR, Patel UI. Formulation and evaluation of transdermal patches of glibenclamide. Int J Pham Res 2009; 1(2): 34-42.
[6]
Kaity S, Ghosh A. Facile preparation of acrylamide grafted locust bean gum poly(vinyl alcohol)interpenetrating polymer network microspheres for controlled oral drug delivery. J Drug Del. Sci Tech (Paris) 2016; 33: 1-12.
[8]
Davidson RL. Handbook of water soluble gums and resins. 1980.
[11]
United States Pharmacopoeia and National Formulary (USP29- NF24) Supplement 1. New York: United States pharmacopeial convention. 2006.
[12]
The Pharmacopoeia of India. New Delhi: Government of India Ministry of Health and Family Welfare 1996.
[13]
Kompellaa SD, Bharathia A, Sowjanyaa K. Formulation and in-vitro evaluation of sustain release matrix tablet of losartan potassium using natural gum. J Drug Del Res 2014; 2(4): 17-33.
[15]
Deb N, Kulkarni SV, Kumar P. Feasibility of using natural gums for development of sustained release matrix tablet of itopride. Der Pharmacia Lettre 2015; 7(3): 114-23.
[16]
Deshmukh VN, Singh SP, Sakarkar D. Formulation and evaluation of sustained release metoprolol succinate tablet using hydrophilic gums as release modifiers. Int J Pharm Tech Res 2009; 1(2): 159-63.
[18]
Ahad AH, Reddy AB, Chandra Shekar A, Ravindra BV. Development and in Vitro evaluation of glibenclamide aloe barbadensis miller leaves mucilage controlled release matrix tablets. Int J Pharm Tech Res 2010; 2(2): 1018-21.
[20]
Stability testing of new drug substances and products note for guidance on stability testing: Stability testing of new drug substances and products European Medicines Evaluation Agency (EMEA) (CPMP/ICH/2736/99). 2003.
[21]
Ahad AH, Meghana M, Navya K, Mallika B. Designing and evaluation of glibenclamideazadirachtaindicamucilage based controlled release matrix tablets. Der Pharmacia Lettre 2010; 2(1): 117-21.
[22]
Jayaswal SR, Felix JV, Viswanath BA. Formulation and evaluation of sustained release matrix tablets of Glibenclamide. Int J Pharm Teach 2014; 6(2): 6572-86.
[23]
Pawan P, Kumar N. Formulation, evaluation and comparison of sustained release matrix tablet of diclofenac sodium using natural polymer. Int J Res Pharm Biomed Sci 2013; 4(1): 367-79.
[25]
Sharma J, Nagpal M, Arora S. Glibenclamide solubility enhancement by modified natural gum carriers using the solid dispersion technique. Farmacia 2012; 60(6): 822-39.
[26]
Garad SV, Jangme CM, Somnathe ND. Application of rheological synergism between hydrophilic gums in the development of sustained release matrix tablets. World J Pharm Pharm Sci 2015; 4(3): 503-12.