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Current Drug Targets

Author(s): Parisa Maleki Dana, Fatemeh Sadoughi, Moein Mobini, Rana Shafabakhsh, Shala Chaichian*, Bahram Moazzami, Maryam Chamani and Zatollah Asemi*

DOI: 10.2174/1389450120666190927123746

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Molecular and Biological Functions of Melatonin in Endometrial Cancer

Page: [519 - 526] Pages: 8

  • * (Excluding Mailing and Handling)

Abstract

Endometrial cancer is the fifth leading cancer among women. This rate is higher in developed countries and its incidence is increasing worldwide. Diabetes mellitus, obesity, hypertension and arteriosclerosis are major risk factors for endometrial cancer. Melatonin is a hormone synthesized in the pineal and extra-pineal organs such as the digestive tract, bone marrow, retina and more. Evidence shows the potential effects of melatonin in endometrial cancer inhibition. Therefore, the focus of this paper is to review this outstanding evidence and to summarize the molecular and biological mechanisms of melatonin for the inhibition of endometrial cancer.

Keywords: Melatonin, pregnancy, endometrial cancer, apoptosis, obesity, bone marrow.

Graphical Abstract

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