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Current Green Chemistry

Author(s): Anxhela Akolli, Silvia Moretti , Francesca Mangiavacchi , Bonifacio Monti and Claudio Santi*

DOI: 10.2174/2213346106666190916105514

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Mild and Green Protocol for Selective Deuteration of Quercetin-3-ORutinoside (Rutin) Under Aqueous Basic Conditions

Page: [147 - 151] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

A convenient and cost-effective method for selective deuteration of rutin using biologically compatible bases and D2O both as a deuterium source and a solvent is herein reported. The protocol is benign and inexpensive affording good results in very mild conditions allowing to reduce the required amount of deuterium oxide. The position of the C-H/C-D exchange and the level of deuteration can be conveniently followed by 1H-NMR.

Keywords: Rutin, arginine, deuterium oxide, NMR, TRIS, solvent.

Graphical Abstract

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