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Current Nanomaterials

Author(s): Pratibha Salunkhe, Priya Bhoyar, Amravati Gode and Sandeep P. Shewale*

DOI: 10.2174/2405461504666190830094917

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Application of Nanotechnology to the Extraction of Herbal Components for Medicinal Uses

Page: [4 - 11] Pages: 8

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Abstract

Herbal medicine is central to Indian medicinal treatment, which has been known as Ayurveda traditionally. There are hundreds of herbs that have the qualities to treat several kinds of diseases, even critical and chronic ones. Importantly, these herbs have hardly any side effects. Herbal medicine is manufactured from herbal extracts. Hence, the method of extracting herbal extracts assumes high importance in manufacturing herbal medicines.

There are several methods for extracting herbs. However, the novel drug delivery system (NDDS)-nanotechnology has been gaining popularity as a method to extract herbal extracts. NDDS offers miraculous promises as it is a complete processing system that combines the methods of drug formulation (pharmaceutics), biochemistry, molecular biology, and process and technology. In this method, a nano-sized drug release system is used to transmit medicines on the targeted parts of the human body safely. NDDS serves many purposes, such as it minimizes the requirement of frequent supervision to conquer refusal, enhances the remedial worth, minimizes toxicity, and rises bioavailability.

There are many advantages to the targeted drug release system, such as it reduces the frequency of the dosages taken by the patients, has a more uniformed effect of the drug, reduces any possibility of side effects, and controls fluctuation in circulating drug levels.

Keywords: Nanotechnology, herbal medication, drug formulation, novel drug delivery system, pharmaceutics and molecular biology, therapeutic effects.

Graphical Abstract

[1]
Yadav D, Suri S, Choudhary AA, Sikender M. Novel approach: herbal remedies and natural products in pharmaceutical science as nano drug delivery systems Int J Pharm Tech 2011; 3: 3092-116.
[2]
Singh RP, Singh SG, Naik H, Jain D, Bisla S. Herbal excipients in novel drug delivery system. Int J Comprehensive Pharm 2011; 2: 1-7.
[3]
Sungthongjeen S, Pitaksuteepong T, Somsiri A, Sriamornsak P. Studies on pectins as potential hydrogel matrices for controlled-release drug delivery. Drug Dev Ind Pharm 1999; 25(12): 1271-6.
[http://dx.doi.org/10.1081/DDC-100102298] [PMID: 10612023]
[4]
Singh RP, Singh SG, Naik H, Jain D, Bisla S. Herbal excipients in novel drug delivery system. Int J Compr Pharm 2011; 2: 1-7.
[5]
Bairwa NK, Sethiya NK, Mishra SH. Protective effect of stem bark of Ceiba pentandra linn. against paracetamol-induced hepatotoxicity in rats. Pharmacognosy Res 2010; 2(1): 26-30.
[http://dx.doi.org/10.4103/0974-8490.60584] [PMID: 21808535]
[6]
Wu XY, Lee PI. Preparation and characterization of thermal- and pH-sensitive nanospheres. Pharm Res 1993; 10(10): 1544-7.
[http://dx.doi.org/10.1023/A:1018900114881] [PMID: 8272420]
[7]
Nikalje AP. Nanotechnology and its applications in medicine. Med Chem 2015; 5: 2.
[8]
Gupta D, Nguyen P, Yu M. Nanoparticles for superior pharmacokinetics and enhanced efficacy. J Dev Drugs 2014; 3: 2.
[9]
Gao D. Drug design for cancer: gold nanoparticle-liposome hybrids for drug delivery and monitoring. Drug Des 2013; 2: 2.
[10]
Lopes CM. Therapeutics delivery: innovations technology approaches. Drug Des 2014; 3: 3.
[11]
Sahni JK, Baboota S, Ali J. Promising role of nanopharmaceuticals in drug delivery. Pharm Times 2011; 43: 16-8.
[12]
Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Eur J Pharm Biopharm 2000; 50(1): 161-77.
[http://dx.doi.org/10.1016/S0939-6411(00)00087-4] [PMID: 10840199]
[13]
Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm 1989; 55: R1-4.
[http://dx.doi.org/10.1016/0378-5173(89)90281-0]
[14]
Jung J, Perrut M. Particle design using supercritical fluids: literature and patent survey. J Supercrit Fluids 2001; 20: 179-219.
[http://dx.doi.org/10.1016/S0896-8446(01)00064-X]
[15]
Yen FL, Wu TH, Lin LT, Cham TM, Lin CC. Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats. Food Chem Toxicol 2008; 46(5): 1771-7.
[http://dx.doi.org/10.1016/j.fct.2008.01.021] [PMID: 18308443]
[16]
Zhang JF, Hou SX, Liu HL. [Comparison of preparing two polylactide nanoparticles loaded lipophilic anti-cancer herb drug by nanoprecipitation method]. Zhongguo Zhongyao Zazhi 2007; 32(4): 303-6.
[PMID: 17455462]
[17]
Li Y, Dong L, Jia A, Chang X, Xue H. Preparation and characterization of solid lipid nanoparticles loaded traditional Chinese medicine. Int J Biol Macromol 2006; 38(3-5): 296-9.
[http://dx.doi.org/10.1016/j.ijbiomac.2006.03.006] [PMID: 16600362]
[18]
Robinson JR. Introduction: semi-solid formulations for oral drug delivery. Bull Tech Gattefosse 1996; 89: 11-3.
[19]
Aungst BJ. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. J Pharm Sci 1993; 82(10): 979-87.
[http://dx.doi.org/10.1002/jps.2600821008] [PMID: 8254497]
[20]
DeMario MD, Ratain MJ. Oral chemotherapy: rationale and future directions. J Clin Oncol 1998; 16(7): 2557-67.
[http://dx.doi.org/10.1200/JCO.1998.16.7.2557] [PMID: 9667278]
[21]
Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev 1997; 25: 47-58.
[http://dx.doi.org/10.1016/S0169-409X(96)00490-5]
[22]
Sethiya NK, Trivedi A, Patel MB, Mishra SH. Comparative pharmacognostical investigation on four ethanobotanicals traditionally used as Shankhpushpi in India. J Adv Pharm Technol Res 2010; 1(4): 388-95.
[http://dx.doi.org/10.4103/0110-5558.76437] [PMID: 22247878]
[23]
Bisht S, Feldmann G. Son Si, Ravi R, Karikar C, Maitra A. Polymeric nanoparticles-encapsulated curcumin (nanocurcumin): a novel strategy for human cancer therapy. J Nanobiotechnology 2007; 5(3): 2-18.
[24]
Sharma RA, Euden SA, Platton SL, et al. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res 2004; 10(20): 6847-54.
[http://dx.doi.org/10.1158/1078-0432.CCR-04-0744] [PMID: 15501961]
[25]
Lim KJ, Bisht S, Bar EE, Maitra A, Eberhart CG. A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors. Cancer Biol Ther 2011; 11(5): 464-73.
[http://dx.doi.org/10.4161/cbt.11.5.14410] [PMID: 21193839]
[26]
Singla AK, Garg A, Aggarwal D. Paclitaxel and its formulations. Int J Pharm 2002; 235(1-2): 179-92.
[http://dx.doi.org/10.1016/S0378-5173(01)00986-3] [PMID: 11879753]
[27]
Spencer CM, Faulds D. Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer. Drugs 1994; 48(5): 794-847.
[http://dx.doi.org/10.2165/00003495-199448050-00009] [PMID: 7530632]
[28]
Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S. Nano-capsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm 1989; 55: 1-4.
[http://dx.doi.org/10.1016/0378-5173(89)90281-0]
[29]
Fukuda K, Hibiya Y, Mutoh M, Koshiji M, Akao S, Fujiwara H. Inhibition of activator protein 1 activity by berberine in human hepatoma cells. Planta Med 1999; 65(4): 381-3.
[http://dx.doi.org/10.1055/s-2006-960795] [PMID: 10364850]
[30]
Lin JG, Chung JG, Wu LT, Chen GW, Chang HL, Wang TF. Effects of berberine on arylamine N-acetyltransferase activity in human colon tumor cells. Am J Chin Med 1999; 27(2): 265-75.
[http://dx.doi.org/10.1142/S0192415X99000306] [PMID: 10467460]
[31]
Kim SA, Kwon Y, Kim JH, Muller MT, Chung IK. Induction of topoisomerase II-mediated DNA cleavage by a protoberberine alkaloid, berberrubine. Biochemistry 1998; 37(46): 16316-24.
[http://dx.doi.org/10.1021/bi9810961] [PMID: 9819224]
[32]
Chen KJ, Tang L, Garcia MA, et al. The therapeutic efficacy of camptothecin-encapsulated supramolecular nanoparticles. Biomaterials 2012; 33(4): 1162-9.
[http://dx.doi.org/10.1016/j.biomaterials.2011.10.044] [PMID: 22074663]
[33]
Shinji S, Yasukazu T, Hatsue W, Kazuo K, Machiko I, Naoki M. Analysis of brain cell activation by nano-sized particles of Ginkgo biloba extract. Int J Plant Physiol Biochem 2011; 3(3): 28-33.
[34]
Wang B, Ma L, Tao X, Lipsky PE. Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription. Arthritis Rheum 2004; 50(9): 2995-303.
[http://dx.doi.org/10.1002/art.20459] [PMID: 15457469]
[35]
Kang DG, Oh H, Sohn EJ, et al. Lithospermic acid B isolated from Salvia miltiorrhiza ameliorates ischemia/reperfusion-induced renal injury in rats. Life Sci 2004; 75(15): 1801-16.
[http://dx.doi.org/10.1016/j.lfs.2004.02.034] [PMID: 15302225]
[36]
Liu JR, Chen GF, Shih HN, Kuo PC. Enhanced antioxidant bioactivity of Salvia miltiorrhiza (Danshen) products prepared using nanotechnology. Phytomedicine 2008; 15(1-2): 23-30.
[http://dx.doi.org/10.1016/j.phymed.2007.11.012] [PMID: 18077145]
[37]
Kawai Y, Nishikawa T, Shiba Y, et al. Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids. J Biol Chem 2008; 283(14): 9424-34.
[http://dx.doi.org/10.1074/jbc.M706571200] [PMID: 18199750]
[38]
Zhu BH, Guan YY, He H, Lin MJ. Effects of Scutellarein on diabetic rat aorta. Acta Pharmacol Sin 2000; 21(4): 353-6.
[PMID: 11324466]
[39]
Yen FL, Wu TH, Lin LT, Cham TM, Lin CC. Naringenin-loaded nanoparticles improve the physicochemical properties and the hepatoprotective effects of naringenin in orally-administered rats with CCl(4)-induced acute liver failure. Pharm Res 2009; 26(4): 893-902.
[http://dx.doi.org/10.1007/s11095-008-9791-0] [PMID: 19034626]