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Current Aging Science

Author(s): Manupriya Chaudhary, Azmi Khan and Madhu Gupta*

DOI: 10.2174/1567205016666190809161115

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Skin Ageing: Pathophysiology and Current Market Treatment Approaches

Page: [22 - 30] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Ageing is a natural phenomenon which is a fold, ridge and crease in the skin that occurs due to loss of body mass, poor hydration, disintegration of dermis and epidermis junction. The Skin ageing process involves many changes that occur due to the combination of both endogenous factors (gene mutation, cellular metabolism, and hormonal factor) and exogenous factors (U.V, pollutants, chemical, and toxins). In 1950, the number of older people were found to be almost 205 million across the globe. But this number almost got 4 times by the year 2012 and the number of older persons increased to a massive amount of 810 million. The ageing of the skin occurs due to various mechanisms like glycation, free radical, cell cycle, and cellular and molecular mechanism of skin ageing. In this review article, we have discussed the treatment, worldwide newer therapies and marketed formulation that are currently available for the reduction of skin ageing. The most promising and revolutionizing field of nanotechnology is mostly applied in the field of dermatology, cosmetics, and biomedical applications. Nanotechnology also plays a vital role in increasing the efficacy of the product.

Keywords: Treatment, nanotechnology, skin ageing, dermatology, nanocarriers, body mass.

Graphical Abstract

[1]
Miguel JD, Carlos HM, David MM. Ageing and the epidemiology of multimorbidity. Eur Respir J 2014; 44(4): 1055-68.
[2]
Gutiérrez AM, Nöbauer K, Soler L, et al. Detection of potential markers for systemic disease in saliva of pigs by proteomics: a pilot study. Vet Immunol Immunopathol 2013; 151(1-2): 73-82.
[http://dx.doi.org/10.1016/j.vetimm.2012.10.007] [PMID: 23177629]
[3]
Bolognia JL, Braverman IM, Rousseau ME, Sarrel PM. Skin changes in menopause. Maturitas 1989; 11(4): 295-304.
[http://dx.doi.org/10.1016/0378-5122(89)90026-1] [PMID: 2693917]
[4]
Castelo-Branco C, Duran M, González-Merlo J. Skin collagen changes related to age and hormone replacement therapy. Maturitas 1992; 15(2): 113-9.
[http://dx.doi.org/10.1016/0378-5122(92)90245-Y] [PMID: 1345134]
[5]
Curtis R, Geesaman BJ, DiStefano PS. Ageing and metabolism: drug discovery opportunities. Nat Rev Drug Discov 2005; 4(7): 569-80.
[http://dx.doi.org/10.1038/nrd1777] [PMID: 15976816]
[6]
Makrantonaki E, Zouboulis CC, William J. Characteristics and pathomechanisms of endogenously aged skin. Dermatology 2007; 214(4): 352-60.
[http://dx.doi.org/10.1159/000100890] [PMID: 17460411]
[7]
Bernstein EF, Chen YQ, Kopp JB, et al. Long-term sun exposure alters the collagen of the papillary dermis. Comparison of sun-protected and photoaged skin by northern analysis, immunohistochemical staining, and confocal laser scanning microscopy. J Am Acad Dermatol 1996; 34(2 Pt 1): 209-18.
[http://dx.doi.org/10.1016/S0190-9622(96)80114-9] [PMID: 8642084]
[8]
Varani J, Spearman D, Perone P, et al. Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro. Am J Pathol 2001; 158(3): 931-42.
[http://dx.doi.org/10.1016/S0002-9440(10)64040-0] [PMID: 11238041]
[9]
Landau M. Exogenous factors in skin aging. Curr Probl Dermatol 2007; 35: 1-13.
[http://dx.doi.org/10.1159/000106405] [PMID: 17641486]
[10]
Leyden JJ. Clinical features of ageing skin. Br J Dermatol 1990; 122(Suppl. 35): 1-3.
[http://dx.doi.org/10.1111/j.1365-2133.1990.tb16118.x] [PMID: 2186777]
[11]
Seité S, Medaisko C, Christiaens F, et al. Biological effects of simulated ultraviolet daylight: a new approach to investigate daily photoprotection. Photodermatol Photoimmunol Photomed 2006; 22(2): 67-77.
[http://dx.doi.org/10.1111/j.1600-0781.2006.00209.x] [PMID: 16606411]
[12]
Piérard-Franchimont C, Letawe C, Goffin V, Piérard GE. Skin water-holding capacity and transdermal estrogen therapy for menopause: a pilot study. Maturitas 1995; 22(2): 151-4.
[http://dx.doi.org/10.1016/0378-5122(95)00924-A] [PMID: 8538484]
[13]
Phillips TJ, Demircay Z, Sahu M. Hormonal effects on skin aging. Europe PMC 2001; 17(4): 661-72.
[14]
Lovell CR, Smolenski KA, Duance VC, Light ND, Young S, Dyson M. Type I and III collagen content and fibre distribution in normal human skin during ageing. Br J Dermatol 1987; 117(4): 419-28.
[http://dx.doi.org/10.1111/j.1365-2133.1987.tb04921.x] [PMID: 3676091]
[15]
Morita A. Tobacco smoke causes premature skin aging. J Dermatol Sci 2007; 48(3): 169-75.
[http://dx.doi.org/10.1016/j.jdermsci.2007.06.015] [PMID: 17951030]
[16]
Zhang S, Duan E. Fighting against skin aging: The way from bench to bedside. Cell Transplant 2018; 27(5): 729-38.
[http://dx.doi.org/10.1177/0963689717725755] [PMID: 29692196]
[17]
Carrel A, Ebeling AH. Age and multiplication of fibroblasts. J Exp Med 1921; 34(6): 599-623.
[http://dx.doi.org/10.1084/jem.34.6.599] [PMID: 19868581]
[18]
Jenkins G. Molecular mechanisms of skin ageing. Mech Ageing Dev 2002; 123(7): 801-10.
[http://dx.doi.org/10.1016/S0047-6374(01)00425-0] [PMID: 11869737]
[19]
Renault V, Throne LE, Eriksson PO. Gillian butler- Browne. Vincemt Mouly 2002; 1(4): 188.
[20]
Shay JW, Wright WE. Hayflick, his limit, and cellular ageing. Nat Rev Mol Cell Biol 2000; 1(1): 72-6.
[http://dx.doi.org/10.1038/35036093] [PMID: 11413492]
[21]
Ly DH, Lockhart DJ, Lerner RA, Schultz PG. Mitotic misregulation and human aging. Science 2000; 287(5462): 2486-92.
[http://dx.doi.org/10.1126/science.287.5462.2486] [PMID: 10741968]
[22]
Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11(3): 298-300.
[http://dx.doi.org/10.1093/geronj/11.3.298] [PMID: 13332224]
[23]
Harman D. Free radical theory of aging mutation. Mutat Res Rev Mutat Res 2003; 5: 5.
[24]
Commoner B, Townsend J, Pake GE. Free radicals in biological materials. Nature 1954; 174(4432): 689-91.
[http://dx.doi.org/10.1038/174689a0] [PMID: 13213980]
[25]
Andrew PW. Ageing and the free radical theory. Respir Physiol 2001; 128(3): 379-91.
[26]
Golias CH, Charalabopoulos A, Charalabopoulos K. Cell proliferation and cell cycle control: a mini review. Int J Clin Pract 2004; 58(12): 1134-41.
[27]
El-Deiry WS, Tokino T, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75: 817-25.
[28]
Buckingham EM, Klingelhutz AJ. The role of telomeres in the ageing of human skin. Exp Dermatol 2011; 20(4): 297-302.
[http://dx.doi.org/10.1111/j.1600-0625.2010.01242.x] [PMID: 21371125]
[29]
Moyzis RK, Buckingham JM, Cram LS, et al. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA 1988; 85(18): 6622-6.
[http://dx.doi.org/10.1073/pnas.85.18.6622] [PMID: 3413114]
[30]
Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermatoendocrinol 2012; 4(3): 308-19.
[http://dx.doi.org/10.4161/derm.22804] [PMID: 23467476]
[31]
Lupo MP, Cole AL. Cosmeceutical peptides. Dermatol Ther 2007; 20(5): 343-9.
[http://dx.doi.org/10.1111/j.1529-8019.2007.00148.x] [PMID: 18045359]
[32]
Nelson BR, Majmudar G, Griffiths CE, et al. Clinical improvement following dermabrasion of photoaged skin correlates with synthesis of collagen I. Arch Dermatol 1994; 130(9): 1136-42.
[http://dx.doi.org/10.1001/archderm.1994.01690090060008] [PMID: 8085868]
[33]
Collins PS. The chemical peel. Clin Dermatol 1987; 5(4): 57-74.
[http://dx.doi.org/10.1016/0738-081X(87)90027-7] [PMID: 3328645]
[34]
Fischer TC, Perosino E, Poli F, Viera MS, Dreno B. Cosmetic dermatology European expert group chemical peels in aesthetic dermatology: An update. J Eur Acad Dermatol Venereol 2010; 24(3): 281-92.
[http://dx.doi.org/10.1111/j.1468-3083.2009.03409.x] [PMID: 19744174]
[35]
Sadick NS. Update on non-ablative light therapy for rejuvenation: a review. Lasers Surg Med 2003; 32(2): 120-8.
[http://dx.doi.org/10.1002/lsm.10127] [PMID: 12561045]
[36]
Alster TS, Garg S. Treatment of facial rhytides with a high-energy pulsed carbon dioxide laser. Plast Reconstr Surg 1996; 98(5): 791-4.
[http://dx.doi.org/10.1097/00006534-199610000-00005] [PMID: 8823015]
[37]
Herne KB, Zachary CB. New facial rejuvenation techniques. Semin Cutan Med Surg 2000; 19(4): 221-31.
[http://dx.doi.org/10.1053/sder.2000.18362] [PMID: 11149603]
[38]
Biesman BS. Fractional ablative skin resurfacing: complications. Lasers Surg Med 2009; 41(3): 177-8.
[http://dx.doi.org/10.1002/lsm.20764] [PMID: 19291748]
[39]
Freymiller EG. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004; 62(4): 1046-7.
[40]
Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004; 62(4): 489-96.
[http://dx.doi.org/10.1016/j.joms.2003.12.003] [PMID: 15085519]
[41]
Krasna M, Domanović D, Tomsic A, Svajger U, Jeras M. Platelet gel stimulates proliferation of human dermal fibroblasts in vitro. Acta Dermatovenerol Alp Panonica Adriat 2007; 16(3): 105-10.
[PMID: 17994170]
[42]
Dessy LA, Mazzocchi M, Rubino C, Mazzarello V, Spissu N, Scuderi N. An objective assessment of botulinum toxin A effect on superficial skin texture. Ann Plast Surg 2007; 58(5): 469-73.
[http://dx.doi.org/10.1097/01.sap.0000244968.16977.1f] [PMID: 17452827]
[43]
Böni R, Kreyden OP, Burg G. Revival of the use of botulinum toxin: application in dermatology. Dermatology 2000; 200(4): 287-91.
[http://dx.doi.org/10.1159/000018389] [PMID: 10894957]
[44]
Coffield JA, Considine RB, Simpson LL. The site and mechanism of action of botulinum neurotoxin Therapy with botulinum toxin. New York: Dekker 1994; pp. 3-14.
[45]
Kishimoto Y, Saito N, Kurita K, Shimokado K, Maruyama N, Ishigami A. Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts. Biochem Biophys Res Commun 2013; 430(2): 579-84.
[http://dx.doi.org/10.1016/j.bbrc.2012.11.110] [PMID: 23228664]
[46]
Yadav NK, Nanda S, Sharma G, Katare OP. Systematically optimized coenzyme q10-loaded novel proniosomal formulation for treatment of photo-induced aging in mice: characterization, biocompatibility studies, biochemical estimations and anti-aging evaluation. J Drug Target 2016; 24(3): 257-71.
[47]
Sapino S, Ugazio E, Gallarate M, Morel S. Resveratrol in solid lipid nanoparticles. J Dispers Sci Technol 2012; 33(4): 465-71.
[http://dx.doi.org/10.1080/01932691.2010.548274]
[48]
Scalia S, Franceschinis E, Bertelli D, Iannuccelli V. Comparative evaluation of the effect of permeation enhancers, lipid nanoparticles and colloidal silica on in vivo human skin penetration of quercetin. Skin Pharmacol Physiol 2013; 25(2): 57-67.
[http://dx.doi.org/10.1159/000345210] [PMID: 23207877]
[49]
Lohan SB, Bauersachs S, Ahlberg S, et al. Ultra-small lipid nanoparticles promote the penetration of coenzyme Q10 in skin cells and counteract oxidative stress. Eur J Pharm Biopharm 2015; 89(1): 201-7.
[http://dx.doi.org/10.1016/j.ejpb.2014.12.008] [PMID: 25500282]