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Current Pharmaceutical Analysis

Author(s): Kubra Ozturk, Nurgul K. Bakirhan, Sibel A. Ozkan and Bengi Uslu*

DOI: 10.2174/1573412915666190802165833

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Sensitive Detection of Levocetirizine as a new Generation Antihistamine by Stripping Square Wave Voltammetry

Page: [424 - 437] Pages: 14

  • * (Excluding Mailing and Handling)

Abstract

Background: A new and selective electrochemical sensor was developed for the determination of levocetirizine dihydrochloride, which is an antihistaminic drug.

Methods: The investigation was performed by using cyclic, differential pulse and square wave voltammetric methods on the β-cyclodextrin modified glassy carbon electrode. It is thereby planned to obtain information about levocetirizine determination and its mechanism.

Results: The efficiency of experimental parameters including pH, scan rate, and accumulation potential and time on the anodic response of levocetirizine dihydrochloride was studied. By employing the developed method and under optimized conditions, the current showed linear dependence with a concentration in the range between 2 × 10-8 M and 6 × 10-6 M in pH 2.0 Britton Robinson (BR) buffer.

Conclusion: The achieved limits of detection and quantification were found as 3.73 × 10-10 M and 1.24 × 10-9 M, respectively. In addition, the possibility of applying the developed sensor for real sample analysis was investigated, so β-cyclodextrin modified glassy carbon electrode was used to determine levocetirizine dihydrochloride in Xyzal® tablet dosage form. Finally, this sensor was successfully applied to the real sample as a selective, simple, reproducible, repeatable electrochemical sensor.

Keywords: Levocetirizine, sensor, drug analysis, electrochemistry, solid electrode, tablet.

Graphical Abstract

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