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Current Pharmaceutical Biotechnology

Author(s): Srishti Vashisht, Harshita Mishra, Pawan K. Mishra, Adam Ekielski and Sushama Talegaonkar*

DOI: 10.2174/1389201020666190802115722

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Structure, Genome, Infection Cycle and Clinical Manifestations Associated with Human Papillomavirus

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Abstract

A small, non-enveloped, obligatory parasite, Human papillomavirus (HPV) is known to be the cause of a range of malignancies. These entail benign infections like genital warts as well as malignant, life-threatening conditions such as cervical cancer. Since a very high mortality rate is associated with HPV caused cancers (cervical cancer is a 2nd leading cause of death caused due to cancer among women globally), there is an escalating need to understand and search for ways to combat such medical conditions. Under the same light, the given article provides an insight into the world of this versatile pathogen. Distinct aspects related to HPV have been discussed here. Emphasis has been laid upon the composition, function and assembly of capsid proteins (structural studies) and various genetic elements and their gene products (genomic studies). The essence of the mechanism behind the development of persistent infection and modes responsible for the transmission of the infectious particles has been briefly covered. Finally, the review outlines various infections and diseases caused by HPV with a major focus on their clinical and histological manifestations.

Keywords: Human Papillomavirus (HPV), major and minor capsid proteins, genome, classification, infection cycle, malignancies, cancer.

Graphical Abstract

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