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Letters in Drug Design & Discovery

Author(s): Nidhi Rani and Randhir Singh*

DOI: 10.2174/1570180815666181015144431

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Design, Synthesis, Antimicrobial Evaluation and Molecular Modeling Study of New 2-mercaptoimidazoles (Series-III)

Page: [512 - 521] Pages: 10

  • * (Excluding Mailing and Handling)

Abstract

Background: A series of novel substituted 2-mercaptoimidazoles was synthesised efficiently and in high yields using one-pot synthesis from m-hydroxyacetophenones.

Methods: The structures of the newly synthesized compounds were established, their molecular activity was investigated against some bacteria and fungi were further validated using molecular docking study.

Results: Reaction of o-hydroxyphenacylbromide (2) with substituted aniline and KSCN, in the presence of catalyst p-toluene sulfonic acid afforded 4(a-r) in good yield. The structure of compounds (4a-r) was confirmed by IR, NMR and MS.

Conclusion: The compounds exhibited excellent antimicrobial potency against the tested microorganism.

Keywords: Mercaptoimidazoles, imidazoles, molecular modeling, antifungal, antibacterial, m-hydroxyacetophenones.

Graphical Abstract

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