[1]
Borén, J.; Williams, K.J. The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: a triumph of simplicity. Curr. Opin. Lipidol., 2016, 27(5), 473-483.
[2]
Gisterå, A.; Hansson, G.K. The immunology of atherosclerosis. Nat. Rev. Nephrol., 2017, 13(6), 368-380.
[3]
Dallinga-Thie, G.M.; Franssen, R.; Mooij, H.L.; Visser, M.E.; Hassing, H.C.; Peelman, F.; Kastelein, J.J.; Péterfy, M.; Nieuwdorp, M. The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight. Atheroscler., 2010, 211(1), 1-8.
[4]
Young, S.G.; Zechner, R. Biochemistry and pathophysiology of intravascular and intracellular lipolysis. Genes Dev., 2013, 27(5), 459-484.
[5]
Hussain, M.M. Intestinal lipid absorption and lipoprotein formation. Curr. Opin. Lipidol., 2014, 25(3), 200-206.
[6]
Abumrad, N.A.; Goldberg, I.J. CD36 actions in the heart: Lipids, calcium, inflammation, repair and more? Biochim. Biophys. Acta, 2016, 1861(10), 1442-1449.
[7]
Williams, K.J. Molecular processes that handle -- and mishandle -- dietary lipids. J. Clin. Invest., 2008, 118(10), 3247-3259.
[8]
Goldstein, J.L.; Brown, M.S. Atherosclerosis: the low-density lipoprotein receptor hypothesis. Metabol., 1977, 26(11), 1257-1275.
[9]
Twickler, T.; Dallinga-Thie, G.M.; Chapman, M.J.; Cohn, J.S. Remnant lipoproteins and atherosclerosis. Curr. Atheroscler. Rep., 2005, 7(2), 140-147.
[10]
Chatterjee, C.; Sparks, D.L. Hepatic lipase, high density lipoproteins, and hypertriglyceridemia. Am. J. Pathol., 2011, 178(4), 1429-1433.
[11]
Ketelhuth, D.F.; Hansson, G.K. Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall. Thromb. Haemost., 2011, 106(5), 779-786.
[12]
Bernelot Moens, S.J.; Neele, A.E.; Kroon, J.; van der Valk, F.M.; Van den Bossche, J.; Hoeksema, M.A.; Hoogeveen, R.M.; Schnitzler, J.G.; Baccara-Dinet, M.T.; Manvelian, G.; de Winther, M.P.J.; Stroes, E.S.G. PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia. Eur. Heart J., 2017, 38(20), 1584-1593.
[13]
Berglund, L.; Brunzell, J.D.; Goldberg, A.C.; Goldberg, I.J.; Sacks, F.; Murad, M.H.; Stalenhoef, A.F. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab., 2012, 97(9), 2969-2989.
[14]
Freiberg, J.J.; Tybjaerg-Hansen, A.; Jensen, J.S.; Nordestgaard, B.G. Nonfasting triglycerides and risk of ischemic stroke in the general population. JAMA, 2008, 300(18), 2142-2152.
[15]
Nordestgaard, B.G.; Benn, M.; Schnohr, P.; Tybjaerg-Hansen, A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA, 2007, 298(3), 299-308.
[16]
Varbo, A.; Benn, M.; Tybjærg-Hansen, A.; Jørgensen, A.B.; Frikke-Schmidt, R.; Nordestgaard, B.G. Remnant cholesterol as a causal risk factor for ischemic heart disease. J. Am. Coll. Cardiol., 2013, 61(4), 427-436.
[17]
Utermann, G.; Menzel, H.J.; Kraft, H.G.; Duba, H.C.; Kemmler, H.G.; Seitz, C. Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma. J. Clin. Invest., 1987, 80(2), 458-465.
[18]
White, A.L.; Lanford, R.E. Cell surface assembly of lipoprotein(a) in primary cultures of baboon hepatocytes. J. Biol. Chem., 1994, 269(46), 28716-28723.
[19]
Lobentanz, E.M.; Dieplinger, H. Biogenesis of lipoprotein(a) in human and animal hepatocytes. Electrophoresis, 1997, 18(14), 2677-2681.
[20]
Reyes-Soffer, G.; Ginsberg, H.N.; Ramakrishnan, R. The metabolism of lipoprotein (a): an ever-evolving story. J. Lipid Res., 2017, 58(9), 1756-1764.
[21]
Willeit, P.; Kiechl, S.; Kronenberg, F.; Witztum, J.L.; Santer, P.; Mayr, M.; Xu, Q.; Mayr, A.; Willeit, J.; Tsimikas, S. Discrimination and net reclassification of cardiovascular risk with lipoprotein(a): prospective 15-year outcomes in the Bruneck Study. J. Am. Coll. Cardiol., 2014, 64(9), 851-860.
[22]
Merki, E.; Graham, M.; Taleb, A.; Leibundgut, G.; Yang, X.; Miller, E.R.; Fu, W.; Mullick, A.E.; Lee, R.; Willeit, P.; Crooke, R.M.; Witztum, J.L.; Tsimikas, S. Antisense oligonucleotide lowers plasma levels of apolipoprotein (a) and lipoprotein (a) in transgenic mice. J. Am. Coll. Cardiol., 2011, 57(15), 1611-1621.
[23]
Nordestgaard, B.G.; Langsted, A. Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology. J. Lipid Res., 2016, 57(11), 1953-1975.
[24]
Tsimikas, S.A. Test in context: lipoprotein(a): diagnosis, prognosis, controversies, and emerging therapies. J. Am. Coll. Cardiol., 2017, 69(6), 692-711.
[25]
van der Valk, F.M.; Bekkering, S.; Kroon, J.; Yeang, C.; Van den Bossche, J.; van Buul, J.D.; Ravandi, A.; Nederveen, A.J.; Verberne, H.J.; Scipione, C.; Nieuwdorp, M.; Joosten, L.A.; Netea, M.G.; Koschinsky, M.L.; Witztum, J.L.; Tsimikas, S.; Riksen, N.P.; Stroes, E.S. Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans. Circulation, 2016, 134(8), 611-624.
[26]
Capoulade, R.; Chan, K.L.; Yeang, C.; Mathieu, P.; Bossé, Y.; Dumesnil, J.G.; Tam, J.W.; Teo, K.K.; Mahmut, A.; Yang, X.; Witztum, J.L.; Arsenault, B.J.; Després, J.P.; Pibarot, P.; Tsimikas, S. Oxidized phospholipids, lipoprotein(a), and progression of calcific aortic valve stenosis. J. Am. Coll. Cardiol., 2015, 66(11), 1236-1246.
[27]
Tsimikas, S.; Mallat, Z.; Talmud, P.J.; Kastelein, J.J.; Wareham, N.J.; Sandhu, M.S.; Miller, E.R.; Benessiano, J.; Tedgui, A.; Witztum, J.L.; Khaw, K.T.; Boekholdt, S.M. Oxidation-specific biomarkers, lipoprotein(a), and risk of fatal and nonfatal coronary events. J. Am. Coll. Cardiol., 2010, 56(12), 946-955.
[28]
Erqou, S.; Kaptoge, S.; Perry, P.L.; Di Angelantonio, E.; Thompson, A.; White, I.R.; Marcovina, S.M.; Collins, R.; Thompson, S.G.; Danesh, J.; Danesh, J. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA, 2009, 302(4), 412-423.
[29]
Erqou, S.; Thompson, A.; Di Angelantonio, E.; Saleheen, D.; Kaptoge, S.; Marcovina, S.; Danesh, J. Apolipoprotein(a) isoforms and the risk of vascular disease: systematic review of 40 studies involving 58,000 participants. J. Am. Coll. Cardiol., 2010, 55(19), 2160-2167.
[30]
Kamstrup, P.R.; Benn, M.; Tybjaerg-Hansen, A.; Nordestgaard, B.G. Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population: the Copenhagen City Heart Study. Circulation, 2008, 117(2), 176-184.
[31]
Langsted, A.; Kamstrup, P.R.; Nordestgaard, B.G. Lipoprotein(a): fasting and nonfasting levels, inflammation, and cardiovascular risk. Atheroscler., 2014, 234(1), 95-101.
[32]
Boerwinkle, E.; Leffert, C.C.; Lin, J.; Lackner, C.; Chiesa, G.; Hobbs, H.H. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J. Clin. Invest., 1992, 90(1), 52-60.
[33]
Utermann, G. The mysteries of lipoprotein(a). Sci., 1989, 246(4932), 904-910.
[34]
Tardif, J.C.; Grégoire, J.; L’Allier, P.L.; Ibrahim, R.; Lespérance, J.; Heinonen, T.M.; Kouz, S.; Berry, C.; Basser, R.; Lavoie, M.A.; Guertin, M.C.; Rodés-Cabau, J. Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial. JAMA, 2007, 297(15), 1675-1682.
[35]
Libby, P. Managing the risk of atherosclerosis: the role of high-density lipoprotein. Am. J. Cardiol., 2001, 88(12A), 3N-8N.
[36]
Kontush, A.; Chapman, M.J. Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis. Pharmacol. Rev., 2006, 58(3), 342-374.
[37]
Ross, R. Atherosclerosis--an inflammatory disease. N. Engl. J. Med., 1999, 340(2), 115-126.
[38]
Hahn, C.; Schwartz, M.A. The role of cellular adaptation to mechanical forces in atherosclerosis. Arterioscler. Thromb. Vasc. Biol., 2008, 28(12), 2101-2107.
[39]
Baratchi, S.; Khoshmanesh, K.; Woodman, O.L.; Potocnik, S.; Peter, K.; McIntyre, P. Molecular sensors of blood flow in endothelial cells. Trends Mol. Med., 2017, 23(9), 850-868.
[40]
Cunningham, K.S.; Gotlieb, A.I. The role of shear stress in the pathogenesis of atherosclerosis. Lab. Invest., 2005, 85(1), 9-23.
[41]
Traub, O.; Berk, B.C. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler. Thromb. Vasc. Biol., 1998, 18(5), 677-685.
[42]
Pan, S. Molecular mechanisms responsible for the atheroprotective effects of laminar shear stress. Antioxid. Redox Signal., 2009, 11(7), 1669-1682.
[43]
VanderLaan, P.A.; Reardon, C.A.; Getz, G.S. Site specificity of atherosclerosis: site-selective responses to atherosclerotic modulators. Arterioscler. Thromb. Vasc. Biol., 2004, 24(1), 12-22.
[44]
Zhou, J.; Li, Y.S.; Chien, S. Shear stress-initiated signaling and its regulation of endothelial function. Arterioscler. Thromb. Vasc. Biol., 2014, 34(10), 2191-2198.
[45]
Won, D.; Zhu, S.N.; Chen, M.; Teichert, A.M.; Fish, J.E.; Matouk, C.C.; Bonert, M.; Ojha, M.; Marsden, P.A.; Cybulsky, M.I. Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow. Am. J. Pathol., 2007, 171(5), 1691-1704.
[46]
Heinecke, J.W.; Baker, L.; Rosen, H.; Chait, A. Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells. J. Clin. Invest., 1986, 77(3), 757-761.
[47]
Botti, H.; Trostchansky, A.; Batthyány, C.; Rubbo, H. Reactivity of peroxynitrite and nitric oxide with LDL. IUBMB Life, 2005, 57(6), 407-412.
[48]
von Eckardstein, A.; Rohrer, L. Transendothelial lipoprotein transport and regulation of endothelial permeability and integrity by lipoproteins. Curr. Opin. Lipidol., 2009, 20(3), 197-205.
[49]
Schwenke, D.C.; Carew, T.E. Initiation of atherosclerotic lesions in cholesterol-fed rabbits. I. Focal increases in arterial LDL concentration precede development of fatty streak lesions. Arterioscler., 1989, 9(6), 895-907.
[50]
Tabas, I.; Williams, K.J.; Borén, J. Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation, 2007, 116(16), 1832-1844.
[51]
Sun, S.W.; Zu, X.Y.; Tuo, Q.H.; Chen, L.X.; Lei, X.Y.; Li, K.; Tang, C.K.; Liao, D.F. Caveolae and caveolin-1 mediate endocytosis and transcytosis of oxidized low density lipoprotein in endothelial cells. Acta Pharmacol. Sin., 2010, 31(10), 1336-1342.
[52]
Frank, P.G.; Pavlides, S.; Cheung, M.W.; Daumer, K.; Lisanti, M.P. Role of caveolin-1 in the regulation of lipoprotein metabolism. Am. J. Physiol. Cell Physiol., 2008, 295(1), C242-C248.
[53]
Fogelstrand, P.; Borén, J. Retention of atherogenic lipoproteins in the artery wall and its role in atherogenesis. Nutr. Metab. Cardiovasc. Dis., 2012, 22(1), 1-7.
[54]
Cancel, L.M.; Fitting, A.; Tarbell, J.M. In vitro study of LDL transport under pressurized (convective) conditions. Am. J. Physiol. Heart Circ. Physiol., 2007, 293(1), H126-H132.
[55]
Dabagh, M.; Jalali, P.; Tarbell, J.M. The transport of LDL across the deformable arterial wall: the effect of endothelial cell turnover and intimal deformation under hypertension. Am. J. Physiol. Heart Circ. Physiol., 2009, 297(3), H983-H996.
[56]
Kang, H.; Cancel, L.M.; Tarbell, J.M. Effect of shear stress on water and LDL transport through cultured endothelial cell monolayers. Atheroscler., 2014, 233(2), 682-690.
[57]
Armstrong, S.M.; Sugiyama, M.G.; Fung, K.Y.; Gao, Y.; Wang, C.; Levy, A. `S.; Azizi, P.; Roufaiel, M.; Zhu, S. N.; Neculai, D.; Yin, C.; Bolz, S.S.; Seidah, N.G.; Cybulsky, M. I.; Heit, B.; Lee, W. L. A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis. Cardiovasc. Res., 2015, 108(2), 268-277.
[58]
Velagapudi, S.; Yalcinkaya, M.; Piemontese, A.; Meier, R.; Nørrelykke, S.F.; Perisa, D.; Rzepiela, A.; Stebler, M.; Stoma, S.; Zanoni, P.; Rohrer, L.; von Eckardstein, A. VEGF-A regulates cellular localization of sr-bi as well as transendothelial transport of HDL but not LDL. Arterioscler. Thromb. Vasc. Biol., 2017, 37(5), 794-803.
[59]
Kraehling, J.R.; Chidlow, J.H.; Rajagopal, C.; Sugiyama, M.G.; Fowler, J.W.; Lee, M.Y.; Zhang, X.; Ramírez, C.M.; Park, E.J.; Tao, B.; Chen, K.; Kuruvilla, L.; Larriveé, B.; Folta-Stogniew, E.; Ola, R.; Rotllan, N.; Zhou, W.; Nagle, M.W.; Herz, J.; Williams, K.J.; Eichmann, A.; Lee, W.L.; Fernández-Hernando, C.; Sessa, W.C. Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nat. Commun., 2016, 7, 13516.
[60]
Skålén, K.; Gustafsson, M.; Rydberg, E.K.; Hultén, L.M.; Wiklund, O.; Innerarity, T.L.; Borén, J. Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature, 2002, 417(6890), 750-754.
[61]
Borén, J.; Olin, K.; Lee, I.; Chait, A.; Wight, T.N.; Innerarity, T.L. Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding. J. Clin. Invest., 1998, 101(12), 2658-2664.
[62]
Boren, J.; Lee, I.; Zhu, W.; Arnold, K.; Taylor, S.; Innerarity, T.L. Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100. J. Clin. Invest., 1998, 101(5), 1084-1093.
[63]
Gerhardt, T.; Ley, K. Monocyte trafficking across the vessel wall. Cardiovasc. Res., 2015, 107(3), 321-330.
[64]
Timmerman, I.; Daniel, A.E.; Kroon, J.; van Buul, J.D. Leukocytes crossing the endothelium: a matter of communication. Int. Rev. Cell Mol. Biol., 2016, 322, 281-329.
[65]
Woollard, K.J.; Geissmann, F. Monocytes in atherosclerosis: subsets and functions. Nat. Rev. Cardiol., 2010, 7(2), 77-86.
[66]
Moore, K.J.; Sheedy, F.J.; Fisher, E.A. Macrophages in atherosclerosis: a dynamic balance. Nat. Rev. Immunol., 2013, 13(10), 709-721.
[67]
Nourshargh, S.; Hordijk, P.L.; Sixt, M. Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat. Rev. Mol. Cell Biol., 2010, 11(5), 366-378.
[68]
Boring, L.; Gosling, J.; Cleary, M.; Charo, I.F. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature, 1998, 394(6696), 894-897.
[69]
Carman, C.V.; Springer, T.A. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J. Cell Biol., 2004, 167(2), 377-388.
[70]
Carman, C.V.; Sage, P.T.; Sciuto, T.E.; de la Fuente, M.A.; Geha, R.S.; Ochs, H.D.; Dvorak, H.F.; Dvorak, A.M.; Springer, T.A. Transcellular diapedesis is initiated by invasive podosomes. Immunity, 2007, 26(6), 784-797.
[71]
van Gils, J.M.; Ramkhelawon, B.; Fernandes, L.; Stewart, M.C.; Guo, L.; Seibert, T.; Menezes, G.B.; Cara, D.C.; Chow, C.; Kinane, T.B.; Fisher, E.A.; Balcells, M.; Alvarez-Leite, J.; Lacy-Hulbert, A.; Moore, K.J. Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions. Arterioscler. Thromb. Vasc. Biol., 2013, 33(5), 911-919.
[72]
Ly, N.P.; Komatsuzaki, K.; Fraser, I.P.; Tseng, A.A.; Prodhan, P.; Moore, K.J.; Kinane, T.B. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc. Natl. Acad. Sci. USA, 2005, 102(41), 14729-14734.
[73]
Zwaginga, J.J.; Torres, H.I.; Lammers, J.; Sixma, J.J.; Koenderman, L.; Kuijper, P.H. Minimal platelet deposition and activation in models of injured vessel wall ensure optimal neutrophil adhesion under flow conditions. Arterioscler. Thromb. Vasc. Biol., 1999, 19(6), 1549-1554.
[74]
Huo, Y.; Schober, A.; Forlow, S.B.; Smith, D.F.; Hyman, M.C.; Jung, S.; Littman, D.R.; Weber, C.; Ley, K. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat. Med., 2003, 9(1), 61-67.
[75]
Langer, H.F.; Gawaz, M. Platelet-vessel wall interactions in atherosclerotic disease. Thromb. Haemost., 2008, 99(3), 480-486.
[76]
da Costa Martins, P.; van den Berk, N.; Ulfman, L.H.; Koenderman, L.; Hordijk, P.L.; Zwaginga, J.J. Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation. Arterioscler. Thromb. Vasc. Biol., 2004, 24(1), 193-199.
[77]
van Gils, J.M.; da Costa Martins, P.A.; Mol, A.; Hordijk, P.L.; Zwaginga, J.J. Transendothelial migration drives dissociation of plateletmonocyte complexes. Thromb. Haemost., 2008, 100(2), 271-279.
[78]
Badrnya, S.; Schrottmaier, W.C.; Kral, J.B.; Yaiw, K.C.; Volf, I.; Schabbauer, G.; Söderberg-Nauclér, C.; Assinger, A. Platelets mediate oxidized low-density lipoprotein-induced monocyte extravasation and foam cell formation. Arterioscler. Thromb. Vasc. Biol., 2014, 34(3), 571-580.
[79]
Libby, P.; Ridker, P.M.; Hansson, G.K. Progress and challenges in translating the biology of atherosclerosis. Nature, 2011, 473(7347), 317-325.
[80]
Frohman, E.M.; Racke, M.K.; Raine, C.S. Multiple sclerosis--the plaque and its pathogenesis. N. Engl. J. Med., 2006, 354(9), 942-955.
[81]
Dutta, P.; Nahrendorf, M. Monocytes in myocardial infarction. Arterioscler. Thromb. Vasc. Biol., 2015, 35(5), 1066-1070.
[82]
Goldstein, J.L.; Brown, M.S. The low-density lipoprotein pathway and its relation to atherosclerosis. Annu. Rev. Biochem., 1977, 46, 897-930.
[83]
Steinberg, D. Oxidative Modification of LDL in the pathogenesis of atherosclerosis. Am. J. Geriatr. Cardiol., 1993, 2(5), 38-41.
[84]
Gleissner, C.A.; Leitinger, N.; Ley, K. Effects of native and modified low-density lipoproteins on monocyte recruitment in atherosclerosis. Hypertension, 2007, 50(2), 276-283.
[85]
Smalley, D.M.; Lin, J.H.; Curtis, M.L.; Kobari, Y.; Stemerman, M.B.; Pritchard, K.A., Jr Native LDL increases endothelial cell adhesiveness by inducing intercellular adhesion molecule-1. Arterioscler. Thromb. Vasc. Biol., 1996, 16(4), 585-590.
[86]
Zhu, Y.; Lin, J.H.; Liao, H.L.; Friedli, O., Jr; Verna, L.; Marten, N.W.; Straus, D.S.; Stemerman, M.B. LDL induces transcription factor activator protein-1 in human endothelial cells. Arterioscler. Thromb. Vasc. Biol., 1998, 18(3), 473-480.
[87]
Verna, L.; Ganda, C.; Stemerman, M.B. In vivo low-density lipoprotein exposure induces intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 correlated with activator protein-1 expression. Arterioscler. Thromb. Vasc. Biol., 2006, 26(6), 1344-1349.
[88]
Lin, J.H.; Zhu, Y.; Liao, H.L.; Kobari, Y.; Groszek, L.; Stemerman, M.B. Induction of vascular cell adhesion molecule-1 by low-density lipoprotein. Atheroscler., 1996, 127(2), 185-194.
[89]
Allen, S.; Khan, S.; Al-Mohanna, F.; Batten, P.; Yacoub, M. Native low density lipoprotein-induced calcium transients trigger VCAM-1 and E-selectin expression in cultured human vascular endothelial cells. J. Clin. Invest., 1998, 101(5), 1064-1075.
[90]
Blacklow, S.C. Versatility in ligand recognition by LDL receptor family proteins: advances and frontiers. Curr. Opin. Struct. Biol., 2007, 17(4), 419-426.
[91]
Steinberg, D. The LDL modification hypothesis of atherogenesis: an update. J. Lipid Res., 2009, 50(Suppl.), S376-S381.
[92]
Saremi, A.; Arora, R. Vitamin E and cardiovascular disease. Am. J. Ther., 2010, 17(3), e56-e65.
[93]
Gregson, J.M.; Freitag, D.F.; Surendran, P.; Stitziel, N.O.; Chowdhury, R.; Burgess, S.; Kaptoge, S.; Gao, P.; Staley, J.R.; Willeit, P.; Nielsen, S.F.; Caslake, M.; Trompet, S.; Polfus, L.M.; Kuulasmaa, K.; Kontto, J.; Perola, M.; Blankenberg, S.; Veronesi, G.; Gianfagna, F.; Männistö, S.; Kimura, A.; Lin, H.; Reilly, D.F.; Gorski, M.; Mijatovic, V.; Munroe, P.B.; Ehret, G.B.; Thompson, A.; Uria-Nickelsen, M.; Malarstig, A.; Dehghan, A.; Vogt, T.F.; Sasaoka, T.; Takeuchi, F.; Kato, N.; Yamada, Y.; Kee, F.; Müller-Nurasyid, M.; Ferrières, J.; Arveiler, D.; Amouyel, P.; Salomaa, V.; Boerwinkle, E.; Thompson, S.G.; Ford, I.; Wouter Jukema, J.; Sattar, N.; Packard, C.J.; Shafi Majumder, A.A.; Alam, D.S.; Deloukas, P.; Schunkert, H.; Samani, N.J.; Kathiresan, S.; Nordestgaard, B.G.; Saleheen, D.; Howson, J.M.; Di Angelantonio, E.; Butterworth, A.S.; Danesh, J. Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles. Eur. J. Prev. Cardiol., 2017, 24(5), 492-504.
[94]
Tellis, C.C.; Tselepis, A.D. Pathophysiological role and clinical significance of lipoprotein-associated phospholipase A2 (Lp-PLA2) bound to LDL and HDL. Curr. Pharm. Des., 2014, 20(40), 6256-6269.
[95]
Steinbrecher, U.P.; Parthasarathy, S.; Leake, D.S.; Witztum, J.L.; Steinberg, D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc. Natl. Acad. Sci. USA, 1984, 81(12), 3883-3887.
[96]
Steinbrecher, U.P. Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products. J. Biol. Chem., 1987, 262(8), 3603-3608.
[97]
Steinbrecher, U.P.; Witztum, J.L.; Parthasarathy, S.; Steinberg, D. Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism. Arterioscler., 1987, 7(2), 135-143.
[98]
Lubos, E.; Handy, D.E.; Loscalzo, J. Role of oxidative stress and nitric oxide in atherothrombosis. Front. Biosci., 2008, 13, 5323-5344.
[99]
Berliner, J.A.; Heinecke, J.W. The role of oxidized lipoproteins in atherogenesis. Free Radic. Biol. Med., 1996, 20(5), 707-727.
[100]
Chen, C.; Khismatullin, D.B. Oxidized low-density lipoprotein contributes to atherogenesis via co-activation of macrophages and mast cells. PLoS One, 2015, 10(3), e0123088.
[101]
Esterbauer, H.; Jürgens, G.; Quehenberger, O.; Koller, E. Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. J. Lipid Res., 1987, 28(5), 495-509.
[102]
Jürgens, G.; Hoff, H.F.; Chisolm, G.M., III; Esterbauer, H. Modification of human serum low density lipoprotein by oxidation--characterization and pathophysiological implications. Chem. Phys. Lipids, 1987, 45(2-4), 315-336.
[103]
Orr, A.W.; Hahn, C.; Blackman, B.R.; Schwartz, M.A. p21-activated kinase signaling regulates oxidant-dependent NF-kappa B activation by flow. Circ. Res., 2008, 103(6), 671-679.
[104]
Yurdagul, A., Jr; Chen, J.; Funk, S.D.; Albert, P.; Kevil, C.G.; Orr, A.W. Altered nitric oxide production mediates matrix-specific PAK2 and NF-κB activation by flow. Mol. Biol. Cell, 2013, 24(3), 398-408.
[105]
Flood, C.; Gustafsson, M.; Pitas, R.E.; Arnaboldi, L.; Walzem, R.L.; Borén, J. Molecular mechanism for changes in proteoglycan binding on compositional changes of the core and the surface of low-density lipoprotein-containing human apolipoprotein B100. Arterioscler. Thromb. Vasc. Biol., 2004, 24(3), 564-570.
[106]
Fu, Z.; Zhou, E.; Wang, X.; Tian, M.; Kong, J.; Li, J.; Ji, L.; Niu, C.; Shen, H.; Dong, S.; Liu, C.; Vermorken, A.; Willard, B.; Zu, L.; Zheng, L. Oxidized low-density lipoprotein-induced microparticles promote endothelial monocyte adhesion via intercellular adhesion molecule 1. Am. J. Physiol. Cell Physiol., 2017, 313(5), C567-C574.
[107]
Yan, F.X.; Li, H.M.; Li, S.X.; He, S.H.; Dai, W.P.; Li, Y.; Wang, T.T.; Shi, M.M.; Yuan, H.X.; Xu, Z.; Zhou, J.G.; Ning, D.S.; Mo, Z.W.; Ou, Z.J.; Ou, J.S. The oxidized phospholipid POVPC impairs endothelial function and vasodilation via uncoupling endothelial nitric oxide synthase. J. Mol. Cell. Cardiol., 2017, 112, 40-48.
[108]
Zhang, C.; Adamos, C.; Oh, M.J.; Baruah, J.; Ayee, M.A.A.; Mehta, D.; Wary, K.K.; Levitan, I. oxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27kip1 signaling: opposite effects of oxLDL and cholesterol loading. Am. J. Physiol. Cell Physiol., 2017, 313(3), C340-C351.
[109]
Ahmadian, M.; Abbott, M.J.; Tang, T.; Hudak, C.S.; Kim, Y.; Bruss, M.; Hellerstein, M.K.; Lee, H.Y.; Samuel, V.T.; Shulman, G.I.; Wang, Y.; Duncan, R.E.; Kang, C.; Sul, H.S. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab., 2011, 13(6), 739-748.
[110]
Le Master, E.; Huang, R.T.; Zhang, C.; Bogachkov, Y.; Coles, C.; Shentu, T.P.; Sheng, Y.; Fancher, I.S.; Ng, C.; Christoforidis, T.; Subbaiah, P.V.; Berdyshev, E.; Qain, Z.; Eddington, D.T.; Lee, J.; Cho, M.; Fang, Y.; Minshall, R.D.; Levitan, I. Proatherogenic flow increases endothelial stiffness via enhanced CD36 (Cluster of Differentiation 36)-Mediated OxLDL (Oxidized Low-Density Lipoprotein) uptake. Arterioscler. Thromb. Vasc. Biol., 2018, 38(1), 64-75.
[111]
Sawamura, T.; Kume, N.; Aoyama, T.; Moriwaki, H.; Hoshikawa, H.; Aiba, Y.; Tanaka, T.; Miwa, S.; Katsura, Y.; Kita, T.; Masaki, T. An endothelial receptor for oxidized low-density lipoprotein. Nature, 1997, 386(6620), 73-77.
[112]
Afonso, M.S.; Castilho, G.; Lavrador, M.S.; Passarelli, M.; Nakandakare, E.R.; Lottenberg, S.A.; Lottenberg, A.M. The impact of dietary fatty acids on macrophage cholesterol homeostasis. J. Nutr. Biochem., 2014, 25(2), 95-103.
[113]
Mollace, V.; Gliozzi, M.; Musolino, V.; Carresi, C.; Muscoli, S.; Mollace, R.; Tavernese, A.; Gratteri, S.; Palma, E.; Morabito, C.; Vitale, C.; Muscoli, C.; Fini, M.; Romeo, F. Oxidized LDL attenuates protective autophagy and induces apoptotic cell death of endothelial cells: Role of oxidative stress and LOX-1 receptor expression. Int. J. Cardiol., 2015, 184, 152-158.
[114]
Marcovecchio, P.M.; Thomas, G.D.; Mikulski, Z.; Ehinger, E.; Mueller, K.A.L.; Blatchley, A.; Wu, R.; Miller, Y.I.; Nguyen, A.T.; Taylor, A.M.; McNamara, C.A.; Ley, K.; Hedrick, C.C. Scavenger receptor CD36 directs nonclassical monocyte patrolling along the endothelium during early atherogenesis. Arterioscler. Thromb. Vasc. Biol., 2017, 37(11), 2043-2052.
[115]
Syväranta, S.; Alanne-Kinnunen, M.; Oörni, K.; Oksjoki, R.; Kupari, M.; Kovanen, P.T.; Helske-Suihko, S. Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis. Atheroscler., 2014, 235(2), 398-407.
[116]
Chen, M.; Masaki, T.; Sawamura, T. LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol. Ther., 2002, 95(1), 89-100.
[117]
Xu, S.; Ogura, S.; Chen, J.; Little, P.J.; Moss, J.; Liu, P. LOX-1 in atherosclerosis: biological functions and pharmacological modifiers. Cell. Mol. Life Sci., 2013, 70(16), 2859-2872.
[118]
Lawrence, T. The nuclear factor NF-kappa B pathway in inflammation. Cold Spring Harb. Perspect. Biol., 2009, 1(6), a001651.
[119]
Cominacini, L.; Pasini, A.F.; Garbin, U.; Davoli, A.; Tosetti, M.L.; Campagnola, M.; Rigoni, A.; Pastorino, A.M.; Lo Cascio, V.; Sawamura, T. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappa B through an increased production of intracellular reactive oxygen species. J. Biol. Chem., 2000, 275(17), 12633-12638.
[120]
Tang, Y.; Zhao, J.; Shen, L.; Jin, Y.; Zhang, Z.; Xu, G.; Huang, X. ox-LDL induces endothelial dysfunction by promoting Arp2/3 complex expression. Biochem. Biophys. Res. Commun., 2016, 475(2), 182-188.
[121]
Hong, D.; Bai, Y.P.; Gao, H.C.; Wang, X.; Li, L.F.; Zhang, G.G.; Hu, C.P. Ox-LDL induces endothelial cell apoptosis via the LOX-1-dependent endoplasmic reticulum stress pathway. Atheroscler., 2014, 235(2), 310-317.
[122]
Tang, F.; Yang, T.L.; Zhang, Z.; Li, X.G.; Zhong, Q.Q.; Zhao, T.T.; Gong, L. MicroRNA-21 suppresses ox-LDL-induced human aortic endothelial cells injuries in atherosclerosis through enhancement of autophagic flux: Involvement in promotion of lysosomal function. Exp. Cell Res., 2017, 359(2), 374-383.
[123]
Lv, J.; Yang, L.; Guo, R.; Shi, Y.; Zhang, Z.; Ye, J. Ox-LDL-induced microRNA-155 promotes autophagy in human endothelial cells via repressing the Rheb/ mTOR pathway. Cell. Physiol. Biochem., 2017, 43(4), 1436-1448.
[124]
Qin, B.; Cao, Y.; Yang, H.; Xiao, B.; Lu, Z. MicroRNA-221/222 regulate ox-LDL-induced endothelial apoptosis via Ets-1/p21 inhibition. Mol. Cell. Biochem., 2015, 405(1-2), 115-124.
[125]
Gencer, B.; Kronenberg, F.; Stroes, E.S.; Mach, F. Lipoprotein(a): the revenant. Eur. Heart J., 2017, 38(20), 1553-1560.
[126]
Leibundgut, G.; Scipione, C.; Yin, H.; Schneider, M.; Boffa, M.B.; Green, S.; Yang, X.; Dennis, E.; Witztum, J.L.; Koschinsky, M.L.; Tsimikas, S. Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a). J. Lipid Res., 2013, 54(10), 2815-2830.
[127]
Bergmark, C.; Dewan, A.; Orsoni, A.; Merki, E.; Miller, E.R.; Shin, M.J.; Binder, C.J.; Hörkkö, S.; Krauss, R.M.; Chapman, M.J.; Witztum, J.L.; Tsimikas, S.A. Novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma. J. Lipid Res., 2008, 49(10), 2230-2239.
[128]
Haque, N.S.; Zhang, X.; French, D.L.; Li, J.; Poon, M.; Fallon, J.T.; Gabel, B.R.; Taubman, M.B.; Koschinsky, M.; Harpel, P.C. CC chemokine I-309 is the principal monocyte chemoattractant induced by apolipoprotein(a) in human vascular endothelial cells. Circulation, 2000, 102(7), 786-792.
[129]
Nakagami, F.; Nakagami, H.; Osako, M.K.; Iwabayashi, M.; Taniyama, Y.; Doi, T.; Shimizu, H.; Shimamura, M.; Rakugi, H.; Morishita, R. Estrogen attenuates vascular remodeling in Lp(a) transgenic mice. Atheroscler., 2010, 211(1), 41-47.
[130]
Zhao, S.P.; Xu, D.Y. Oxidized lipoprotein(a) enhanced the expression of P-selectin in cultured human umbilical vein endothelial cells. Thromb. Res., 2000, 100(6), 501-510.
[131]
Takami, S.; Yamashita, S.; Kihara, S.; Ishigami, M.; Takemura, K.; Kume, N.; Kita, T.; Matsuzawa, Y. Lipoprotein(a) enhances the expression of intercellular adhesion molecule-1 in cultured human umbilical vein endothelial cells. Circulation, 1998, 97(8), 721-728.
[132]
Pellegrino, M.; Furmaniak-Kazmierczak, E.; LeBlanc, J.C.; Cho, T.; Cao, K.; Marcovina, S.M.; Boffa, M.B.; Côté, G.P.; Koschinsky, M.L. The apolipoprotein(a) component of lipoprotein(a) stimulates actin stress fiber formation and loss of cell-cell contact in cultured endothelial cells. J. Biol. Chem., 2004, 279(8), 6526-6533.
[133]
Park, S.Y.; Lee, J.H.; Kim, Y.K.; Kim, C.D.; Rhim, B.Y.; Lee, W.S.; Hong, K.W. Cilostazol prevents remnant lipoprotein particle-induced monocyte adhesion to endothelial cells by suppression of adhesion molecules and monocyte chemoattractant protein-1 expression via lectin-like receptor for oxidized low-density lipoprotein receptor activation. J. Pharmacol. Exp. Ther., 2005, 312(3), 1241-1248.
[134]
Adams, D.H.; Shaw, S. Leucocyte-endothelial interactions and regulation of leucocyte migration. Lancet, 1994, 343(8901), 831-836.
[135]
Norata, G.D.; Grigore, L.; Raselli, S.; Seccomandi, P.M.; Hamsten, A.; Maggi, F.M.; Eriksson, P.; Catapano, A.L. Triglyceride-rich lipoproteins from hypertriglyceridemic subjects induce a pro-inflammatory response in the endothelium: Molecular mechanisms and gene expression studies. J. Mol. Cell. Cardiol., 2006, 40(4), 484-494.
[136]
Williams, C.M.; Maitin, V.; Jackson, K.G. Triacylglycerol-rich lipoprotein-gene interactions in endothelial cells. Biochem. Soc. Trans., 2004, 32(Pt 6), 994-998.
[137]
Maggi, F.M.; Raselli, S.; Grigore, L.; Redaelli, L.; Fantappiè, S.; Catapano, A.L. Lipoprotein remnants and endothelial dysfunction in the postprandial phase. J. Clin. Endocrinol. Metab., 2004, 89(6), 2946-2950.
[138]
Wilmink, H.W.; Twickler, M.B.; Banga, J.D.; Dallinga-Thie, G.M.; Eeltink, H.; Erkelens, D.W.; Rabelink, T.J.; Stroes, E.S. Effect of statin versus fibrate on postprandial endothelial dysfunction: role of remnant-like particles. Cardiovasc. Res., 2001, 50(3), 577-582.
[139]
Ceriello, A.; Assaloni, R.; Da Ros, R.; Maier, A.; Piconi, L.; Quagliaro, L.; Esposito, K.; Giugliano, D. Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients. Circulation, 2005, 111(19), 2518-2524.
[140]
Shin, H.K.; Kim, Y.K.; Kim, K.Y.; Lee, J.H.; Hong, K.W. Remnant lipoprotein particles induce apoptosis in endothelial cells by NAD(P)H oxidase-mediated production of superoxide and cytokines via lectin-like oxidized low-density lipoprotein receptor-1 activation: prevention by cilostazol. Circulation, 2004, 109(8), 1022-1028.
[141]
Wang, L.; Sapuri-Butti, A.R.; Aung, H.H.; Parikh, A.N.; Rutledge, J.C. Triglyceride-rich lipoprotein lipolysis increases aggregation of endothelial cell membrane microdomains and produces reactive oxygen species. Am. J. Physiol. Heart Circ. Physiol., 2008, 295(1), H237-H244.
[142]
Dichtl, W.; Nilsson, L.; Goncalves, I.; Ares, M.P.; Banfi, C.; Calara, F.; Hamsten, A.; Eriksson, P.; Nilsson, J. Very low-density lipoprotein activates nuclear factor-kappaB in endothelial cells. Circ. Res., 1999, 84(9), 1085-1094.
[143]
Bernelot Moens, S.J.; Verweij, S.L.; Schnitzler, J.G.; Stiekema, L.C.A.; Bos, M.; Langsted, A.; Kuijk, C.; Bekkering, S.; Voermans, C.; Verberne, H.J.; Nordestgaard, B.G.; Stroes, E.S.G.; Kroon, J. Remnant cholesterol elicits arterial wall inflammation and a multilevel cellular immune response in humans. Arterioscler. Thromb. Vasc. Biol., 2017, 37(5), 969-975.
[144]
Tarkin, J.M.; Joshi, F.R.; Rudd, J.H. PET imaging of inflammation in atherosclerosis. Nat. Rev. Cardiol., 2014, 11(8), 443-457.
[145]
Rosenson, R.S.; Brewer, H.B., Jr; Ansell, B.J.; Barter, P.; Chapman, M.J.; Heinecke, J.W.; Kontush, A.; Tall, A.R.; Webb, N.R. Dysfunctional HDL and atherosclerotic cardiovascular disease. Nat. Rev. Cardiol., 2016, 13(1), 48-60.
[146]
Haase, C.L.; Tybjærg-Hansen, A.; Qayyum, A.A.; Schou, J.; Nordestgaard, B.G.; Frikke-Schmidt, R. LCAT, HDL cholesterol and ischemic cardiovascular disease: a Mendelian randomization study of HDL cholesterol in 54,500 individuals. J. Clin. Endocrinol. Metab., 2012, 97(2), E248-E256.
[147]
Di Angelantonio, E.; Gao, P.; Pennells, L.; Kaptoge, S.; Caslake, M.; Thompson, A.; Butterworth, A.S.; Sarwar, N.; Wormser, D.; Saleheen, D.; Ballantyne, C.M.; Psaty, B.M.; Sundström, J.; Ridker, P.M.; Nagel, D.; Gillum, R.F.; Ford, I.; Ducimetiere, P.; Kiechl, S.; Koenig, W.; Dullaart, R.P.; Assmann, G.; D’Agostino, R.B., Sr; Dagenais, G.R.; Cooper, J.A.; Kromhout, D.; Onat, A.; Tipping, R.W.; Gómez-de-la-Cámara, A.; Rosengren, A.; Sutherland, S.E.; Gallacher, J.; Fowkes, F.G.; Casiglia, E.; Hofman, A.; Salomaa, V.; Barrett-Connor, E.; Clarke, R.; Brunner, E.; Jukema, J.W.; Simons, L.A.; Sandhu, M.; Wareham, N.J.; Khaw, K.T.; Kauhanen, J.; Salonen, J.T.; Howard, W.J.; Nordestgaard, B.G.; Wood, A.M.; Thompson, S.G.; Boekholdt, S.M.; Sattar, N.; Packard, C.; Gudnason, V.; Danesh, J.; Danesh, J. Lipid-related markers and cardiovascular disease prediction. JAMA, 2012, 307(23), 2499-2506.
[148]
Campbell, S.; Genest, J. HDL-C: clinical equipoise and vascular endothelial function. Expert Rev. Cardiovasc. Ther., 2013, 11(3), 343-353.
[149]
Annema, W.; von Eckardstein, A. Dysfunctional high-density lipoproteins in coronary heart disease: implications for diagnostics and therapy. Transl. Res., 2016, 173, 30-57.
[150]
Aviram, M. Atherosclerosis: cell biology and lipoproteins--inflammation and oxidative stress in atherogenesis: protective role for paraoxonases. Curr. Opin. Lipidol., 2011, 22(3), 243-244.
[151]
Nofer, J.R.; Geigenmüller, S.; Göpfert, C.; Assmann, G.; Buddecke, E.; Schmidt, A. High density lipoprotein-associated lysosphingolipids reduce E-selectin expression in human endothelial cells. Biochem. Biophys. Res. Commun., 2003, 310(1), 98-103.
[152]
Mosig, S.; Rennert, K.; Büttner, P.; Krause, S.; Lütjohann, D.; Soufi, M.; Heller, R.; Funke, H. Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism. BMC Med. Genomics, 2008, 1, 60.
[153]
Tacke, F.; Alvarez, D.; Kaplan, T.J.; Jakubzick, C.; Spanbroek, R.; Llodra, J.; Garin, A.; Liu, J.; Mack, M.; van Rooijen, N.; Lira, S.A.; Habenicht, A.J.; Randolph, G.J. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J. Clin. Invest., 2007, 117(1), 185-194.
[154]
den Hartigh, L.J.; Connolly-Rohrbach, J.E.; Fore, S.; Huser, T.R.; Rutledge, J.C. Fatty acids from very low-density lipoprotein lipolysis products induce lipid droplet accumulation in human monocytes. J. Immunol., 2010, 184(7), 3927-3936.
[155]
Gower, R.M.; Wu, H.; Foster, G.A.; Devaraj, S.; Jialal, I.; Ballantyne, C.M.; Knowlton, A.A.; Simon, S.I. CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler. Thromb. Vasc. Biol., 2011, 31(1), 160-166.
[156]
Xu, L.; Dai Perrard, X.; Perrard, J.L.; Yang, D.; Xiao, X.; Teng, B.B.; Simon, S.I.; Ballantyne, C.M.; Wu, H. Foamy monocytes form early and contribute to nascent atherosclerosis in mice with hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol., 2015, 35(8), 1787-1797.
[157]
Wu, H.; Gower, R.M.; Wang, H.; Perrard, X.Y.; Ma, R.; Bullard, D.C.; Burns, A.R.; Paul, A.; Smith, C.W.; Simon, S.I.; Ballantyne, C.M. Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia. Circulation, 2009, 119(20), 2708-2717.
[158]
Sotiriou, S.N.; Orlova, V.V.; Al-Fakhri, N.; Ihanus, E.; Economopoulou, M.; Isermann, B.; Bdeir, K.; Nawroth, P.P.; Preissner, K.T.; Gahmberg, C.G.; Koschinsky, M.L.; Chavakis, T. Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin. FASEB J., 2006, 20(3), 559-561.
[159]
Patel, S.; Drew, B.G.; Nakhla, S.; Duffy, S.J.; Murphy, A.J.; Barter, P.J.; Rye, K.A.; Chin-Dusting, J.; Hoang, A.; Sviridov, D.; Celermajer, D.S.; Kingwell, B.A. Reconstituted high-density lipoprotein increases plasma high-density lipoprotein anti-inflammatory properties and cholesterol efflux capacity in patients with type 2 diabetes. J. Am. Coll. Cardiol., 2009, 53(11), 962-971.
[160]
Patel, V.K.; Williams, H.; Li, S.C.H.; Fletcher, J.P.; Medbury, H.J. Monocyte inflammatory profile is specific for individuals and associated with altered blood lipid levels. Atheroscler., 2017, 263, 15-23.
[161]
Murphy, A.J.; Woollard, K.J.; Hoang, A.; Mukhamedova, N.; Stirzaker, R.A.; McCormick, S.P.; Remaley, A.T.; Sviridov, D.; Chin-Dusting, J. High-density lipoprotein reduces the human monocyte inflammatory response. Arterioscler. Thromb. Vasc. Biol., 2008, 28(11), 2071-2077.
[162]
Iqbal, A.J.; Barrett, T.J.; Taylor, L.; McNeill, E.; Manmadhan, A.; Recio, C.; Carmineri, A.; Brodermann, M.H.; White, G.E.; Cooper, D.; DiDonato, J.A.; Zamanian-Daryoush, M.; Hazen, S.L.; Channon, K.M.; Greaves, D.R.; Fisher, E.A. Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo. eLife, 2016, 5, 5.
[163]
Ginhoux, F.; Jung, S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat. Rev. Immunol., 2014, 14(6), 392-404.
[164]
Dutta, P.; Sager, H.B.; Stengel, K.R.; Naxerova, K.; Courties, G.; Saez, B.; Silberstein, L.; Heidt, T.; Sebas, M.; Sun, Y.; Wojtkiewicz, G.; Feruglio, P.F.; King, K.; Baker, J.N.; van der Laan, A.M.; Borodovsky, A.; Fitzgerald, K.; Hulsmans, M.; Hoyer, F.; Iwamoto, Y.; Vinegoni, C.; Brown, D.; Di Carli, M.; Libby, P.; Hiebert, S.W.; Scadden, D.T.; Swirski, F.K.; Weissleder, R.; Nahrendorf, M. Myocardial infarction activates CCR2(+) hematopoietic stem and progenitor cells. Cell Stem Cell, 2015, 16(5), 477-487.
[165]
Libby, P.; Nahrendorf, M.; Swirski, F.K. Leukocytes link local and systemic inflammation in ischemic cardiovascular disease: an expanded “cardiovascular continuum”. J. Am. Coll. Cardiol., 2016, 67(9), 1091-1103.
[166]
Morrison, S.J.; Scadden, D.T. The bone marrow niche for haematopoietic stem cells. Nature, 2014, 505(7483), 327-334.
[167]
Suda, T.; Arai, F.; Hirao, A. Hematopoietic stem cells and their niche. Trends Immunol., 2005, 26(8), 426-433.
[168]
Rahman, M.S.; Murphy, A.J.; Woollard, K.J. Effects of dyslipidaemia on monocyte production and function in cardiovascular disease. Nat. Rev. Cardiol., 2017, 14(7), 387-400.
[169]
Blue, E.K.; Ballman, K.; Boyle, F.; Oh, E.; Kono, T.; Quinney, S.K.; Thurmond, D.C.; Evans-Molina, C.; Haneline, L.S. Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats. Pediatr. Res., 2015, 77(2), 316-325.
[170]
Yvan-Charvet, L.; Pagler, T.; Gautier, E.L.; Avagyan, S.; Siry, R.L.; Han, S.; Welch, C.L.; Wang, N.; Randolph, G.J.; Snoeck, H.W.; Tall, A.R. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Sci., 2010, 328(5986), 1689-1693.
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