Abstract

This work reports the synthesis of several 3-methoxycarbonyl-γ-butyrolactone derivatives (4-12) starting from dimethyl itaconate (1), an aryl bromide (2), and a carbonyl compound (3). The synthetic protocol used microwave irradiation, argon atmosphere, and acetonitrile as solvent. The synthesis furnished the target compounds in 80-96% yield; reactions lasted about 10-20 min.

Keywords: γ-butyrolactone, 3-methoxycarbonyl-γ-butyrolactone, aryl bromide, biologically active compounds, carbonyl compounds, dimethyl itaconate, ESI MS data, MCR, microwave irradiation, microwave-assisted synthesis, multicomponent reaction, NMR data, one pot reaction, organic synthesis.

Graphical Abstract