Abstract

The aim and objective of the present work was to prepare and develop hydrochlorothiazide (HCTZ) nanoparticles for quick and complete release by nanonization technique to overcome the poor water solubility and bioavailability problems. The poor solubility of many drugs along with a slow dissolution rate is a major research and industrial problems for pharmaceutical scientists and industries who are included in pill disclosure and medication improvement. It has been accounted for that something like 40% of the mixes are defectively water dissolvable or basically insoluble in water. HCTZ nanoparticles were prepared by solvent evaporation method under ultra-sonication process. Prepared nanoparticles were evaluated for the yield, drug loading and entrapment efficiency studies. HCTZ nanoparticles were also characterized for drug and polymer interaction by using FT-IR and DSC. Morphological characteristics of the formulation were studied by particle size analysis and surface charge, XRD, and FE-SEM. Additionally, in vitro drug dissolution study and ex vivo drug diffusion study were performed. All the characterization studies together revealed that the ideal properties of HCTZ nanoparticles. From the study, we can conclude that the solvent evaporation method under ultra-sonication is a promising method to produce small, uniform and stable HCTZ nanoparticles.

Keywords: Ex vivo and in vitro release profile, hydrochlorothiazide nanoparticle, nanonisation, solubility.