Drug Metabolism Letters

Author(s): Liang Cui, Wan Chan, Feng Qiu, Zongwei Cai and Xinsheng Yao

DOI: 10.2174/187231208786734148

Identification of Four Urea Adducts of Andrographolide in Humans

Page: [261 - 268] Pages: 8

  • * (Excluding Mailing and Handling)

Abstract

Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.

Keywords: Andrographolide, metabolites, urea adducts, human urine, NMR, HRSI-MS