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Current Chemical Biology

Author(s): Farah Kenza Benattia*, Zoheir Arrar, Fayçal Dergal and Youssef Khabbal

DOI: 10.2174/0122127968263950231127051454

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Synergistic Effect, and Therapeutic Potential of Aqueous Prickly Pear Extract. In vivo Neuroleptic, Catatonic, and Hypoglycemic Activity

Page: [216 - 225] Pages: 10

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Abstract

Background: Prickly pear "Opuntia ficus indica (L.) Mill. "otherwise known as the Indian fig tree, belongs to the family Cactaceae, and was known as a medicinal plant for its rich source of bioactive substances.

Objective: The present work aims to promote prickly pear seeds for traditional therapy by phenolic profiling and pharmacological tests of aqueous extract.

Method: An analytical quantification was performed by UV-Visible, and the identification of different bioactive compounds was done by HPLC-DAD. For pharmacological screening, an in vivo evaluation of the various tests, neuroleptic activity which consists of testing the recovery reflex; catatonic activity which is a test to detect catalepsy that can be characterized in animals by the administration of neuroleptic drugs; and for hypoglycemic activity a test was performed to assess glucose tolerance.

Results: The administration of aqueous extract of the prickly pear seeds at a dose (400 mg/kg) allows a reduction in blood sugar with a maximum decrease of one and a half hours compared to the control group.

Conclusion: This work makes it possible to postulate that the extract of prickly pear seeds is associated with a very interesting antihyperglycemic activity given its high content of phenolic compounds.

Keywords: Nopal, seeds, diabetes, hypnosis, therapy, pharmacological, phytochemical screening.

Graphical Abstract

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