Abstract

Recently nanotechnology has emerged with more attention to the cosmetic industry. Formulations for skin whitening are widely applied but hyperpigmentation treatment remains unnoticed. This review summarises use of nanotechnology in hyperpimentaion. Various organic and inorganic nanoparticles used in cosmeceuticals are explained. Various approaches for treatment of hyperpigmentation, barriers for Nanodelivery, availability of organic and inorganic synthetic nanoparticles are stated in the study. The advantages and disadvantages of these organic and inorganic compounds are enlisted. Special emphasis has been given to natural substances including arbutin, Aloesin, hesperidin, niacinamide, liquorice, mulberry, polyphenols, ginseng, gingko which are used used in hyperpigmentation. Regulatory challenges and issues for clinical translation, Patents and publications available in last 20 years related to nanotechnology in hyperpigmentation are discussed in brief. It has been observed that amongst nanocosmeceuticals used for hyperpigmentation, lipid nanoparticles are most widely used due to more skin permeability, biocompatibility, and biodegradable nature. Nonetheless, investigation on health effects and safety profile of nanomaterials are essential for understanding the impact of using these materials.

Keywords: Arbutin, cosmeceuticals, liposomes, nanodelivery, nanoparticles, pigmentation, polyphenols.