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Current Women`s Health Reviews

Author(s): Filippo Alberto Ferrari*, Simone Garzon Garz, Francesca Cisotto, Stefano Uccella and Massimo Franchi

DOI: 10.2174/1573404818666220520152808

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What is the Role of Tranexamic Acid in the Management of Postpartum Haemorrhage? State of Art and Perspectives

Article ID: e200522205092 Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

Primary postpartum haemorrhage (PPH) complicates the postpartum up to 11% of deliveries with different incidences based on geographical regions and is the first cause of maternal deaths, accounting for 25% of cases. Tranexamic acid may play a role in the delicate postpartum balance in case of PPH, inhibiting the conversion of plasminogen to plasmin and reducing the degradation of fibrin. We analyze literature evidence and the possible role of tranexamic acid in clinical practice and future scenarios.

Keywords: Tranexamic acid, vaginal delivery, caesarean section, primary postpartum haemorrhage, obstetric care, uterine atony

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