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Current Stem Cell Research & Therapy

Author(s): Mengze Zhang, Kan Wang, Chunran Xue, Chong Xie, Ze Wang, Yaying Song, Haojun Yu, Yong Hao* and Yangtai Guan*

DOI: 10.2174/1574888X17666220410221905

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Preclinical Studies on Neural Stem/Progenitor Cell Therapy for Ischemic Stroke: A Systematic Review

Page: [380 - 390] Pages: 11

  • * (Excluding Mailing and Handling)

Abstract

Background: Neural stem/progenitor cells (NSPCs) transplantation has been recognized in recent years as an effective strategy for the treatment of ischemic stroke. Several preclinical studies have demonstrated the feasibility, safety, and efficacy of NSPCs therapy.

Methods: We conducted a systematic review of the published literature in Pubmed reporting the use of NSPCs in preclinical studies between 2010 and 2021. Based on the articles reporting data, the key factors affecting efficacy were listed.

Results: A total of 71 preclinical studies, including 91 treatment arms, were identified. The results showed that several factors could influence the outcomes of NSPCs transplantation, including the type of donor cells, cell dose, time of administration after stroke, delivery route, and anesthetic. Treatment outcomes were measured by infarct volume, behavioral tests, and molecular and cellular level results.

Conclusion: Most of the preclinical studies reported statistically significant effects and very few adverse reactions. Transplantation of NSPCs for ischemic stroke still needs to be optimized for several key factors. A standardized treatment outcome assessment could ease the translation of evidence in clinical settings.

Keywords: Neural stem cells, transplantation, ischemic stroke, treatment outcome, animal experimentation, safety.

Graphical Abstract

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