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Current Drug Targets

Author(s): Karim Hemati, Mohammad Hossein Pourhanifeh, Iman Fatemi, Azam Hosseinzadeh and Saeed Mehrzadi*

DOI: 10.2174/1389450123666220114151654

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Anti-Degenerative Effect of Melatonin on Intervertebral Disc: Protective Contribution against Inflammation, Oxidative Stress, Apoptosis, and Autophagy

Page: [711 - 718] Pages: 8

  • * (Excluding Mailing and Handling)

Abstract

Intervertebral disc (IVD) degeneration is a leading cause of lower back pain. Although the etiology of IVD degeneration (IVDD) is unclear, excessive oxidative stress, inflammation and apoptosis, and disruption of autophagy play an important role in the pathogenesis of IVDD. Therefore, finding a solution to mitigate these processes could stop or reduce the development of IVDD. Melatonin, a powerful antioxidant, plays an important role in regulating cartilage tissue hemostasis. Melatonin inhibits the destruction of the extracellular matrix (ECM) of the disc. Melatonin preserves ECM contents, including sox-9, aggrecan, and collagen II through inhibiting matrix degeneration enzymes such as MMP-13. These protective effects may be mediated by the inhibition of oxidative stress, inflammation and apoptosis, and regulation of autophagy in IVD cells.

Keywords: Melatonin, intervertebral disc degeneration, oxidative stress, inflammation, apoptosis, autophagy.

Graphical Abstract

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