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Current Drug Safety

Author(s): Ichrak B. Abdallah*, Sonia Ben Nasr, Chadia Chourabi, Aref Zribi, Mehdi Balti, Wafa Fehri and Abderrazek Haddaoui

DOI: 10.2174/1574886316666210811155102

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Gemcitabine-Related Atrial Fibrillation: A Case Report and Review of the Literature

Page: [70 - 74] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

Introduction: Gemcitabine is a commonly used antimetabolite that has been effective in a broad spec- trum of tumors so far. The main grade three and four known toxicity of this drug is myelosuppres- sion. Cardiac adverse events have been rarely reported and gemcitabine-induced Atrial-Fibrillation (AF) has been described in only five previous cases so far. Here we report the 6th case of gemc- itabine-related AF.

Case Presentation: A 68-year-old man diagnosed with metastatic nasopharyngeal cancer was referred to our oncology department. He started first-line chemotherapy with gemcitabine and cisplatin. He presented poorly tolerated atrial fibrillation related to gemcitabine infusion that lasted for six days. The treatment was then withdrawn, and the patient received the best supportive care.

Conclusion: We conclude that medical oncologists and cardiologists should be aware of such toxicities of gemc- itabine, especially in the elderly who seem to be at a higher risk of such adverse events and which may dictate discontinuation of the drug.

Keywords: Gemcitabine, arrhythmia, atrial fibrillation, antimetabolites, chemotherapy, cisplatin.

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