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Anti-Cancer Agents in Medicinal Chemistry

Author(s): Atif Ali Khan Khalil*, Asma Saleem Qazi, Abdul Nasir, Mi-Jeong Ahn, Muhammad Ajmal Shah*, Muhammad Saad Ahmad, Wasim Sajjad, Tahir Ali, Muhammad Naeem, Fawad Ali Shah, Muhammad Tufail Ahmed Khan, Muhammad Romman, Shahfiq Ur Rehman, Adnan Haider and Raishma Noor

DOI: 10.2174/1871520621666210623095636

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2-Methoxy-6-Acetyl-7-Methyljuglone: A Bioactive Phytochemical with Potential Pharmacological Activities

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Abstract

Natural products have been the focus of biomedical and pharmaceutical research to develop new therapies in recent years. 2-methoxy-6-acetyl-7-methyljuglone (2-methoxystypandrone, MAM) a natural bioactive juglone derivative, is known to have various levels of pharmacotherapeutic efficacies as an anti-inflammatory, anticancer, antioxidant, antimicrobial, and anti-HIV activities. MAM fights cancer progression by inducing apoptosis, necroptosis and deregulating signaling pathways through H2O2-induced JNK/iNOS/NO and MAPK, ERK1/2 pathways, JNK activation, and the RIP1/RIP3 complex. In this review, we summarize the pharmacological importance of MAM in the field of drug discovery. Furthermore, this review not only emphasizes the medicinal properties of MAM, but also discusses its potential efficacy in future medicinal products.

Keywords: 2-Methoxy-6-acetyl-7-methyljuglone, antioxidant, anticancer, anti-inflammatory, antibacterial, MAPK.

Graphical Abstract

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