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Current Bioactive Compounds

Author(s): Youness Kadil* and Houda Filali

DOI: 10.2174/1573407217666210222090038

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The Neuropharmacological Preclinical Effects of Nigella sativa: A Review

Article ID: e190721191621 Pages: 3

  • * (Excluding Mailing and Handling)

Abstract

Background: Many research papers have demonstrated that Nigella has neurotropic properties, and it has also been shown that Nigella seeds have several activities, such as analgesic, antiepileptic, anxiolytic, antidepressant, and psychostimulant activities.

Methods: Databases such as PubMed, Science Direct, Scopus, and Google Scholar were used.

Results: The orientation towards this type of research has become more accentuated to enhance and detail the pharmacological properties of medicinal, aromatic plants.

Conclusion: The present review reveals and combines the experimental research studies carried out to demonstrate the central effects of Nigella.

Keywords: Nigella, preclinical effects, depression, anxiety, neuropharmacology, thymoquinone.

Graphical Abstract

[1]
Ali, B.H.; Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Phytother. Res., 2003, 17(4), 299-305.
[http://dx.doi.org/10.1002/ptr.1309] [PMID: 12722128]
[2]
Khare, M. Indian herbal remedies: Rational Western therapy, ayurvedic, and other traditional usage. Botany, 2004, 35, 400-102.
[3]
Cheikh-Rouhou, S.; Besbes, S.; Hentati, B.; Blecker, C.; Deroanne, C.; Attia, H. Nigella sativa L. chemical composition and physicochemical characteristics of the lipid fraction. Food Chem., 2007, 101, 673-681.
[http://dx.doi.org/10.1016/j.foodchem.2006.02.022]
[4]
Merfort, I.; Wray, V.; Barakat, H.; Hussein, S.A.M.; Nawwar, M.A.M.; Willuhn, G. Flavonoltriglycosides from seeds of Nigella sativa. Phytochemistry, 1997, 46, 359-363.
[http://dx.doi.org/10.1016/S0031-9422(97)00296-3]
[5]
Ramadan, M.F.; Mörsel, J.T. Characterization of phospholipid composition of black cumin (Nigella sativa L.) seed oil. Nahrung, 2002, 46(4), 240-244. a
[http://dx.doi.org/10.1002/1521-3803(20020701)46:4<240::AID-FOOD240>3.0.CO;2-1] [PMID: 12224418]
[6]
Gali-Muhtasib, H.; El-Najjar, N.; Schneider-Stock, R. The medicinal potential of black seed (Nigella sativa) and its components. Adv. Phytomed., 2006, 2, 133-153.
[http://dx.doi.org/10.1016/S1572-557X(05)02008-8]
[7]
Samarghandian, S.; Farkhondeh, T.; Samini, F. A review on possible therapeutic effect of Nigella sativa and thymoquinone in neurodegenerative diseases. CNS Neurol. Disord. Drug Targets, 2018, 17(6), 412-420.
[http://dx.doi.org/10.2174/1871527317666180702101455] [PMID: 29962349]
[8]
Amin, B.; Taheri, M.M.; Hosseinzadeh, H. Effects of intraperitoneal thymoquinone on chronic neuropathic pain in rats. Planta Med., 2014, 80(15), 1269-1277.
[http://dx.doi.org/10.1055/s-0034-1383062] [PMID: 25272235]
[9]
zadeh, H. Study on the anticonvulsant activity of thymoquinone, the major constituent of Nigella sativa L. seeds, through intracerebroventricular injection. J. Med. Plants, 2005, 4, 45-52.
[10]
Javidi, S.; Razavi, B.M.; Hosseinzadeh, H. A review of neuropharmacology effects of Nigella sativa and its main component, thymoquinone. Phytother. Res., 2016, 30(8), 1219-1229.
[http://dx.doi.org/10.1002/ptr.5634] [PMID: 27169925]
[11]
Khanna, T.; Zaidi, F.A.; Dandiya, P.C. CNS and analgesic studies on Nigella sativa. Fitoterapia, 1993, 64, 407-410.
[12]
Kanter, M.; Coskun, O.; Uysal, H. The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage. Arch. Toxicol., 2006, 80(4), 217-224.
[http://dx.doi.org/10.1007/s00204-005-0037-1] [PMID: 16240107]
[13]
Al-Naggar, T.B.; Gómez-Serranillos, M.P.; Carretero, M.E.; Villar, A.M. Neuropharmacological activity of Nigella sativa L. extracts. J. Ethnopharmacol., 2003, 88(1), 63-68.
[http://dx.doi.org/10.1016/S0378-8741(03)00157-0] [PMID: 12902052]
[14]
Al-Ghamdi, M.S. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J. Ethnopharmacol., 2001, 76(1), 45-48.
[http://dx.doi.org/10.1016/S0378-8741(01)00216-1] [PMID: 11378280]
[15]
Hosseinzadeh, H.; Parvardeh, S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine, 2004, 11(1), 56-64.
[http://dx.doi.org/10.1078/0944-7113-00376] [PMID: 14971722]
[16]
Ilhan, A.; Gurel, A.; Armutcu, F.; Kamisli, S.; Iraz, M. Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice. Neuropharmacology, 2005, 49(4), 456-464.
[http://dx.doi.org/10.1016/j.neuropharm.2005.04.004] [PMID: 15913671]
[17]
Shawki, M.; El Wakeel, L.; Shatla, R.; El-Saeed, G.; Ibrahim, S.; Badary, O. The clinical outcome of adjuvant therapy with black seed oil on intractable paediatric seizures: A pilot study. Epileptic Disord., 2013, 15(3), 295-301.
[http://dx.doi.org/10.1684/epd.2013.0602] [PMID: 23981722]
[18]
Heba, S. The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: A comparison with valproate. Neurochem. Res., 2011, 36(11), 2195-2204.
[19]
Randhawa, M.A.; Al-Ghamdi, M.S. A review of pharmaco-therapeutic effects of Nigella sativa. Pak. J. Med. Res., 2002, 41, 77-83.
[20]
Perveen, T.; Haider, S.; Zuberi, N.A.; Saleem, S.; Sadaf, S.; Batool, Z. Increased 5-HT levels following repeated administration of Nigella sativa L. (black seed) oil produce antidepressant effects in rats. Sci. Pharm., 2013, 82(1), 161-170.
[http://dx.doi.org/10.3797/scipharm.1304-19] [PMID: 24634848]
[21]
Hosseini, M.; Zakeri, S.; Khoshdast, S.; Yousefian, F.T.; Rastegar, M.; Vafaee, F.; Kahdouee, S.; Ghorbani, F.; Rakhshandeh, H.; Kazemi, S.A. The effects of Nigella sativa hydro-alcoholic extract and thymoquinone on lipopolysaccharide - induced depression like behavior in rats. J. Pharm. Bioallied Sci., 2012, 4(3), 219-225.
[http://dx.doi.org/10.4103/0975-7406.99052] [PMID: 22923964]
[22]
Huong, D.T.; Choi, H.C.; Rho, T.C.; Lee, H.S.; Lee, M.K.; Kim, Y.H. Inhibitory activity of monoamine oxidase by coumarins from Peucedanum japonicum. Arch. Pharm. Res., 1999, 22(3), 324-326.
[http://dx.doi.org/10.1007/BF02976373] [PMID: 10403141]
[23]
Perveen, T.; Haider, S.; Kanwal, S.; Haleem, D.J. Repeated administration of Nigella sativa decreases 5-HT turnover and produces anxiolytic effects in rats. Pak. J. Pharm. Sci., 2009, 22(2), 139-144.
[PMID: 19339222]
[24]
Farh, M.; Kadil, Y.; Tahri, E.H.; Abounasr, M.; Riad, F.; El Khasmi, M.; Tazi, A. Evaluation of the anxiolytic, antidepressant and memory effects of black seed oil in rats. Phytotherapie, 2018, 16(1), 5-13.
[http://dx.doi.org/10.1007/s10298-017-1095-7]
[25]
Gilhotra, N.; Dhingra, D. Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels. Pharmacol. Rep., 2011, 63, 660-669.
[26]
Raza, M.; El-hadiyah, T.M.; Al-shabanah, O.A. Nigella sativa seed constituents and anxiety relief in experimental models. J. Herbs Spices Med. Plants, 2006, 12, 153-164.
[http://dx.doi.org/10.1300/J044v12n01_14]
[27]
Tamadonfard, Z.; Sepehrara, L.; Johari, H. The effect of Nigella sativa extract on learning and spatial memory of adult male rats. J. Jahrom Univ. Med. Sci., 2014, 12(1), 29-37.
[http://dx.doi.org/10.29252/jmj.12.1.27]
[28]
Bin Sayeed, M.S.; Asaduzzaman, M.; Morshed, H.; Hossain, M.M.; Kadir, M.F.; Rahman, M.R. The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers. J. Ethnopharmacol., 2013, 148(3), 780-786.
[http://dx.doi.org/10.1016/j.jep.2013.05.004] [PMID: 23707331]
[29]
Beheshti, F.; Hosseini, M.; Shafei, M.N.; Soukhtanloo, M.; Ghasemi, S.; Vafaee, F.; Zarepoor, L. The effects of Nigella sativa extract on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats. J. Tradit. Complement. Med., 2016, 6(2), 146-152.
[http://dx.doi.org/10.1016/j.jtcme.2014.11.039] [PMID: 27114937]
[30]
Radad, K.; Rudolf, M.; Mokhtar, T. Thymoquinone protects dopaminergic neurons against MPP+ and rotenone. Phytother. Res., 2009, 23(5), 696-700.
[31]
Naz, H. Nigella sativa: The miraculous herb. Pak. J. Biochem. Mol. Biol., 2011, 44(1), 44-48.
[32]
Mohammed, E.T.; Hashem, K.S.; Rheim, M.R.A. Biochemical study on the impact of Nigella sativa and virgin olive oils on cadmium-induced nephrotoxicity and neurotoxicity in rats. Am. J. Physiol. Biochem. Pharmacol., 2014, 3(2), 71-78.
[33]
Sedaghat, R.; Roghani, M.; Khalili, M. Neuroprotective effect of thymoquinone, the Nigella sativa bioactive compound, in 6-hydroxydopamine-induced hemi-parkinsonian rat model. Iran. J. Pharm. Res., 2014, 13(1), 227-234.
[PMID: 24734075]