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Current Organic Chemistry

Author(s): Bhupinder Kapoor*, Monica Gulati, Reena Gupta, Sachin Kumar Singh, Mukta Gupta, Arshid Nabi and Pooja A. Chawla

DOI: 10.2174/1385272824999201126214150

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A Review on Plant Flavonoids as Potential Anticancer Agents

Page: [737 - 747] Pages: 11

  • * (Excluding Mailing and Handling)

Abstract

Flavonoids are polyphenolic compounds that are mainly derived from fruits and vegetables and constitute an essential part of plant-derived beverages such as green tea, wine and cocoa-based products. They have been shown to possess anticancer effects via different mechanisms such as carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis and differentiation, inhibition of angiogenesis, anti-oxidation and reversal of multidrug resistance or a combination of any two or more of these mechanisms. The present review summarizes the chemistry, biosynthesis and anticancer evaluation of flavonoids in both animal and human studies. A special emphasis has been placed on the flavonoids that are being screened in different phases of clinical trials for chemoprotective action against various cancers.

Keywords: Flavonoids, anticancer, chemoprotection, clinical trials, apoptosis, antiproliferation.

Graphical Abstract

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