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Current Drug Research Reviews

Author(s): Inderbir Singh*, Ajay Kumar Thakur, Rajni Bala and Reecha Madan

DOI: 10.2174/2589977512666200928113716

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SeDeM Expert System, an Innovative Tool for Developing Directly Compressible Tablets: A Review

Page: [16 - 24] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Background: SeDeM (Sediment Delivery Model) expert system is a preformulation tool employed for evaluating direct compression suitability of various excipients. SeDeM is a 12 parameters derived diagram and SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) is a 15 parameters derived diagram that can be used as a research tool for reducing the product development time. The best possible excipients for a specified pharmaceutical active ingredient could be screened for direct compression suitability.

Objective: SeDeM expert system has been successfully used and implemented for characterizing galenic properties of pharmaceutical excipients, direct compression suitability of excipients, development of ODT formulations, development of sustained-release formulations, and development of tablets of taste-masked drugs.

Conclusion: In the present review paper, the development and applications of SeDeM and SeDeMODT systems have been discussed in detail.

Keywords: SeDeM, SeDeM-ODT, direct compression, excipients, tablets, application.

Graphical Abstract

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