Abstract
Background: Dysmenorrhea is one of the most frequent pelvic pains among young
women, impairing their quality of life.
Objective: This research aims to investigate the effect of ginger-chamomile herbs with honey in
reducing dysmenorrhea pain, associated symptoms, and the extent of bleeding.
Methods: In this randomized clinical trial (IRCT No.: 2016100825031N5), 200 female students
with primary dysmenorrhea, from Arak universities, were included and randomly divided into two
groups. All the students were evaluated for one cycle without intervention, then group (A) received
mefenamic acid (250 mg) and group (B) received ginger (1000 mg), chamomile (5000 mg), and one
teaspoonful of honey for two days before and for the first three days of menstruation, three times a
day, in two consecutive cycles. Pain severity, associated symptoms of dysmenorrhea, and bleeding
were assessed using a visual analogue scale, Andersch-Milsom Verbal Scale, and Higham chart.
Data were analyzed by descriptive and inferential statistical tests through SPSS21.
Results: The pain intensity in group B diminished significantly after the intervention in comparison
to group A (p <0.05). The mean severity of dysmenorrhea accompanying symptoms decreased significantly
in group B compared to group A (P=0.009). However, the mean quantity of bleeding
significantly decreased in group A (P = 0.004), with no increase in the extent of bleeding in group B.
Conclusion: The present study indicated that the combination of the ginger-chamomile sachet with
honey has the same effect as nonsteroidal anti-inflammatory drugs for pain mitigation, and the associated
symptoms reduced better than mefenamic acid.
Keywords:
Complementary medicine, dysmenorrhea, pain, ginger, honey, chamomile.
Graphical Abstract
[6]
Berek J, Novak E. Berek and Novak’s gynecology. 15th ed. Philadelphia: Lippincott Williams &Wilkins 2016.
[11]
Saei Gharenaz M, Ozgoli G. Effect of medicinal plants in the treatment of primary dysmenorrhea in Iran: a review article. IJOGI 2015; 18(160): 14-31.
[12]
Babazadeh R, Keramat A. Premenstrual syndrome and complementary medicine in Iran: a systematic review. Feyz 2011; 15(2): 174-87.
[13]
Karimian Z, Sadat Z, Abedzadeh M, et al. Comparison the effect of mefenamic acid and matricaria chamomilla on primary dysmenorrhea in Kashan Medical University students. J Ardabil Univ Med Sci 2013; 13(4): 413-20.
[14]
Jenabi E, Ebrahimzadeh S. Chamomile tea for relief of primary dysmenorrhea. IJOGI 2010; 13(1): 39-42.
[15]
Davdabady Farahani M, Vakilian K, Seyyedzadeh Aghdam N, Ranjbaran M. The effect of valerian and ginger on dysmenorrhea-A randomized clinical trial. IJWHR 2020; 8: 101-5.
[21]
Mirbagher Ajorpaz N, Hafezi M, Salehi S, Tayebi A, Shenasa F, Zantabchi S. Comparing the effect of pure and impure honey on severity of pain, amount of bleeding, and duration and interval of menstrual cycles in female students with primary dysmenorrhea. Evid Based Care J 2012; 2(1): 23-33.
[24]
Kamaliroosta Z, Kamaliroosta L, Elhamirad A. Isolation and identification of ginger essential oil. J Food Biosci Technol 2013; 3: 73-80.
[28]
Kavuluru VKSKP. A study to assess the effectiveness of ginger preparation on dysmenorrhea among adolescent girls. IJAR 2017; 3(3): 22-5.
[30]
Rajabzaheh F, Fazljou SM, Khodaie L, Abbasalizadeh S, Sahebi L. Effects of hot temperament herbs on primary dysmenorrhea: a systematic review. World Fam Med J 2018; 16(3): 257-63.
[35]
Markelov V, Trushin M. Bee venom therapy and low dose naltrexone for treatment of multiple sclerosis. Nepal J Neurosci 2006; 3(2): 71-7.
[43]
Pena D, Montes de Oca N, Rojas S. Anti-inflammatory and anti-diarrheic activity of Isocarpha cubana Blake. Pharmacologyonline 2006; 3: 744-9.