Synthesis and Biological Activity of Quaternary Quinolinium Salts: A Review

Divya       Utreja; Shivali       Sharma; Akhil       Goyal; Komalpreet       Kaur; Sonia       Kaushal
Abstract

Heterocyclic chemistry is the only branch of chemistry that has applications in varied areas such as dyes, photosensitizers, coordination compounds, polymeric materials, biological, and many other fields. Quinoline and its derivatives have always engrossed both synthetic chemists and biologists because of their diverse chemical and pharmacological properties as these ring systems can be easily found in various natural products, especially in alkaloids. Among alkaloids, quinoline derivatives i.e. quinolinium salts have attracted much attention nowadays owing to their diverse biological profile such as antimicrobial, antitumor, antifungal, hypotensive, anti-HIV, analgesics and anti-inflammatory, etc. Quinoline and its analogs have recently been examined for their modes of function in the inhibition of tyrosine kinases, proteasome, tubulin polymerization, topoisomerase, and DNA repair. These observations have been guiding scientists for the expansion of new quinoline derivatives with improved and varied biological activities. Quinolinium salts have immense possibilities and scope to investigate these compounds as potential drug candidates. Therefore, we shall present a concise compilation of this work to aid in present knowledge and to help researchers explore an interesting quinoline class having medicinal potential.
Keywords: Quinoline, quinolinium salts, antimicrobial, alkyl halide, cationic surfactants, antifungal, anticancer, sensors.
Graphical Abstract

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Cite As
Current Organic Chemistry

Synthesis and Biological Activity of Quaternary Quinolinium Salts: A Review

Abstract

Graphical Abstract
